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	Bmtoll9, an arthropod conservative toll, is likely involved in the local gut immune response in the silkworm, bombyx mori
	Wu, Shan1; Zhang, Xiaofeng2; Chen, Xiaomei2; Cao, Pingsheng1; Beerntsen, Brenda T.3; Ling, Erjun1
刊名	Developmental and comparative immunology
	2010-02-01
卷号	34期号:2页码:93-96
关键词	Bmtoll9 Rt-qpcr Expression Bombyx mori Sequence conservation Arthropods
ISSN号	0145-305X
DOI	10.1016/j.dci.2009.08.010
通讯作者	Ling, erjun(erjunling@sippe.ac.cn)
英文摘要	The toll family of transmembrane proteins mediates signaling during the innate immune response in most animals. toll9 is widespread in insects and has a unique signature, qhr, in its toll/interleukin-1 receptor (tir) domain. the introns in the tir region are highly conserved among insects, suggesting the antiquity of toll9 genes. toll9 of bombyx mori (bmtoll9) was analysed by quantitative real-time rt-pcr. bmtoll9 is constitutively expressed in egg, larval and adult stages prior to microbial challenge. bmtoll9 is strongly expressed in the different parts of the gut, but weakly expressed in haemocytes, trachea, fat body, malpighian tubule and epidermis, and scarcely expressed in the silk glands. the injection of sterilized 0.85% nacl solution inhibited bmtoll9 expression in most tissues especially during the early responses. staphylococcus aureus had no or limited effect on the expression of bmtoll9 in the silkworm gut and fat body. but in epidermis, trachea, malpighian tubules and haemocytes, the expression of bmtoll9 was significantly increased after s. aureus challenge. infection of escherichia coli significantly increased the bmtoll9 expression in different parts of the gut as well as in epidermis, malpighian tubule and haemocytes. at 48 h after feeding of the fungus, beauveria bassiana, bmtoll9 expression was significantly increased. tissues responses to the injected and ingested bacteria showed that bmtoll9 is probably involved in the local gut immune response in the silkworm. (c) 2009 elsevier ltd. all rights reserved.
WOS关键词	INNATE IMMUNITY ; DOMESTICATED SILKWORM ; GENES ; DROSOPHILA ; INFECTION ; INSECTS ; DEFENSE ; MAMMALS
WOS研究方向	Immunology ; Zoology
WOS类目	Immunology ; Zoology
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000273147400001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2407190
专题	中国科学院大学
通讯作者	Ling, Erjun
作者单位	1.Chinese Acad Sci, Grad Sch, Res Ctr Insect Sci, Inst Plant Physiol & Ecol,Shanghai Inst Biol Sci, Shanghai 200032, Peoples R China 2.Zhejiang Entry Exit Inspect & Quarantine Bur, Hangzhou 310012, Zhejiang, Peoples R China 3.Univ Missouri, Dept Vet Pathobiol, Coll Vet Meterinary Med, Columbia, MO 65211 USA
推荐引用方式 GB/T 7714	Wu, Shan,Zhang, Xiaofeng,Chen, Xiaomei,et al. Bmtoll9, an arthropod conservative toll, is likely involved in the local gut immune response in the silkworm, bombyx mori[J]. Developmental and comparative immunology,2010,34(2):93-96.
APA	Wu, Shan,Zhang, Xiaofeng,Chen, Xiaomei,Cao, Pingsheng,Beerntsen, Brenda T.,&Ling, Erjun.(2010).Bmtoll9, an arthropod conservative toll, is likely involved in the local gut immune response in the silkworm, bombyx mori.Developmental and comparative immunology,34(2),93-96.
MLA	Wu, Shan,et al."Bmtoll9, an arthropod conservative toll, is likely involved in the local gut immune response in the silkworm, bombyx mori".Developmental and comparative immunology 34.2(2010):93-96.

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