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	Accumulation and oxidative stress biomarkers in japanese flounder larvae and juveniles under chronic cadmium exposure
	Cao, Liang1,2; Huang, Wei1,2; Liu, Jinhu1,2; Yin, Xuebo1; Dou, Shuozeng1
刊名	Comparative biochemistry and physiology c-toxicology & pharmacology
	2010-04-01
卷号	151期号:3页码:386-392
关键词	Oxidative stress Antioxidants and lpo Toxicity Paralichthys olivaceus
ISSN号	1532-0456
DOI	10.1016/j.cbpc.2010.01.004
通讯作者	Dou, shuozeng(szdou@qdio.ac.cn)
英文摘要	This study investigated how cd exposure affected oxidative biomarkers in japanese flounder, paralichthys olivaceus, at early life stages (els). fish were exposed to waterborne cd (0-48 mu g l(-1)) from embryonic to juvenile stages for 80 days. growth, cd accumulation, activities of superoxide dismutase (sod, ec 1.15.1.1), catalase (cat, ec 1.11.1.6), glutathione s-transferase (gst, ec 2.5.1.18), and levels of glutathione (gsh) and lipid peroxidation (lpo) were investigated at three developmental stages. flounder growth decreased and cd accumulation increased with increasing cd concentration. in metamorphosing larvae, cat and sod activities were inhibited and gsh level was elevated, while lpo was enhanced by increasing cd concentrations. cat and gst activities of settling larvae were inhibited but gsh level was elevated at high cd concentrations. in juveniles, sod activity and lpo level were increased but gst activity was inhibited as cd concentration increased. antioxidants in flounder at els were able to develop ductile responses to defend against oxidative stress, but lpo fatally occurred due to cd exposure. these biochemical parameters could be used as effective oxidative biomarkers for evaluating cd contamination and toxicity in marine environments: cat, sod, gsh, and lpo for metamorphosing stage: cat, gsh, and gst for settling stage; and sod, gst, and lpo for juvenile stage. (c) 2010 elsevier inc. all rights reserved.
WOS关键词	FRESH-WATER FISH ; PARALICHTHYS-OLIVACEUS ; LIPID-PEROXIDATION ; OREOCHROMIS-NILOTICUS ; SEA BREAM ; TISSUES ; METALLOTHIONEIN ; GLUTATHIONE ; BLOOD ; BIOACCUMULATION
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology
WOS类目	Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000275627400016
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2406095
专题	中国科学院大学
通讯作者	Dou, Shuozeng
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Cao, Liang,Huang, Wei,Liu, Jinhu,et al. Accumulation and oxidative stress biomarkers in japanese flounder larvae and juveniles under chronic cadmium exposure[J]. Comparative biochemistry and physiology c-toxicology & pharmacology,2010,151(3):386-392.
APA	Cao, Liang,Huang, Wei,Liu, Jinhu,Yin, Xuebo,&Dou, Shuozeng.(2010).Accumulation and oxidative stress biomarkers in japanese flounder larvae and juveniles under chronic cadmium exposure.Comparative biochemistry and physiology c-toxicology & pharmacology,151(3),386-392.
MLA	Cao, Liang,et al."Accumulation and oxidative stress biomarkers in japanese flounder larvae and juveniles under chronic cadmium exposure".Comparative biochemistry and physiology c-toxicology & pharmacology 151.3(2010):386-392.

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