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	Sesamin inhibits bacterial formylpeptide-induced inflammatory responses in a murine air-pouch model and in thp-1 human monocytes
	Cui, Youhong1,3; Hou, Xinwei1,2; Chen, Juan1; Xie, Lianying1; Yang, Lang3,4; Le, Yingying1,2
刊名	Journal of nutrition
	2010-02-01
卷号	140期号:2页码:377-381
ISSN号	0022-3166
DOI	10.3945/jn.109.117804
通讯作者	Le, yingying(yyle@sibs.ac.cn)
英文摘要	The reaction of human leukocytes to chemoattractants is an important component of the host immune response and also plays a crucial role in the development of inflammation. sesamin has been shown to inhibit lipid peroxidation and regulate cytokine production. in this study, we examined the effect of sesamin on inflammatory responses elicited by the bacterial chemotactic peptide n-formyl-methionyl-leucyl-phenylalanine (fmlf) in vitro and in vivo and explored the mechanisms involved. fmlf is recognized by a human g protein-coupled receptor formyl peptide receptor (fpr) on phagocytic leukocytes. sesamin at concentrations between 12.5 and 50 mu mol/l inhibited fmlf-induced chemotaxis of human monocyte cell line thp-1 differentiated with dibutyryl cyclic amp (p < 0.01). similarly, sesamin inhibited fpr-transfected rat basophilic leukemia cell [epitope-tagged human fpr (etfr) cell] migration toward fmlf (p < 0.01). in fmlf-induced inflammation in a murine air-pouch model, intraperitoneal administration of sesamin (12 mg.kg(-1)-d(-1) for 2 d) suppressed leukocyte infiltration in to the air pouch induced by fmlf [(62.89 +/- 7.93) x 10(4) vs. (19.67 +/- 4.43) x 10(4) cells/air pouch; n = 9; p < 0.001]. ca2+ mobilization and mitogen-activated protein kinase extracellular signal-regulated kinase (erk1/2) activation are involved in fmlf-induced leukocyte migration. pretreatment of etfr cells with sesamin inhibited fmlf-induced erk1/2 phosphorylation in a dose-dependent manner but did not affect fmlf-induced ca2+, flux, electrophoretic mobility shift assay showed that pretreatment of thp-1 cells with sesamin dose dependently inhibited fmlf-induced nuclear factor-kappa b (nf-kappa b) activation. these results suggest that sesamin inhibits leukocyte activation by fmlf through erk1/2- and nf-kappa b-related signaling pathways and thus is a potential compound for the management of inflammatory diseases. j. nutr. 140: 377-381, 2010.
WOS关键词	FACTOR-KAPPA-B ; FMET-LEU-PHE ; CARDIOVASCULAR HYPERTROPHY ; CHEMOKINE RECEPTORS ; CELLS ; RATS ; HYPERTENSION ; PROTECTION ; ALPHA ; IDENTIFICATION
WOS研究方向	Nutrition & Dietetics
WOS类目	Nutrition & Dietetics
语种	英语
出版者	AMER SOC NUTRITION-ASN
WOS记录号	WOS:000273799300023
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2405752
专题	中国科学院大学
通讯作者	Le, Yingying
作者单位	1.Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China 3.Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China 4.Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400038, Peoples R China
推荐引用方式 GB/T 7714	Cui, Youhong,Hou, Xinwei,Chen, Juan,et al. Sesamin inhibits bacterial formylpeptide-induced inflammatory responses in a murine air-pouch model and in thp-1 human monocytes[J]. Journal of nutrition,2010,140(2):377-381.
APA	Cui, Youhong,Hou, Xinwei,Chen, Juan,Xie, Lianying,Yang, Lang,&Le, Yingying.(2010).Sesamin inhibits bacterial formylpeptide-induced inflammatory responses in a murine air-pouch model and in thp-1 human monocytes.Journal of nutrition,140(2),377-381.
MLA	Cui, Youhong,et al."Sesamin inhibits bacterial formylpeptide-induced inflammatory responses in a murine air-pouch model and in thp-1 human monocytes".Journal of nutrition 140.2(2010):377-381.

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