QQ客服 官方微博 反馈留言

	Structural immunology and crystallography help immunologists see the immune system in action: how t and nk cells touch their ligands
	Chen, Yong1,2; Shi, Yi1,2; Cheng, Hao1,2; An, Yun-Qing; Gao, George F.1,2,3
刊名	Iubmb life
	2009-06-01
卷号	61期号:6页码:579-590
关键词	T cell Nk cell Structural immunology Crystallography Immune system Receptor Ligand Interaction Mhc Hla Kir Lilr
ISSN号	1521-6543
DOI	10.1002/iub.208
通讯作者	Gao, george f.(gaof@im.ac.cn)
英文摘要	Host immune system is an important and sophisticated system, maintaining the balance of host response to "foreign" antigens and ignorance to the normal-self. to fulfill this achievement the system manipulates a cell-cell interaction through appropriate interactions between cell-surface receptors and cell-surface ligands, or cell-secreted soluble effector molecules to their ligands/receptors/counter-receptors on the cell surface, triggering further downstream signaling for response effects. t cells and nk cells are important components of file immune system for defending the infections and malignancies and maintaining the proper response against over-reaction to the host. receptors on the surface of t cells and nk cells include a number of important protein molecules, for example, t cell receptor (tcr), co-receptor cd8 or cd4, co-stimulator cd28, ctla4, kir, cd94/nkg2, lilr (ilt/lir/cd85), ly49, and so forth. these receptor molecules interact with their ligands on the target cells, including major histocompatibility complex (mhc) (or human leukocyte antigen, hla), cd80, cd86, and so forth. detailed understanding of these receptor-ligand pair interactions is crucial for our full knowledge of the immune system, ultimately for us to manipulate the t cell and nk cell functions. accumulations of the receptor-ligand complex crystal structures in the recent years have provided us a unique angel to see how the immune cells interacting with their partner cells. in this review, we discussed binding specificitiy, plasticity, and flexibility of the t cell and nk cell receptor/ligand interaction, fitting the structural data with their functions. structural immunology indeed helps its see how t and nk cells "touch" their target cells in our immune system. (c) 2009 iubmb iubmb life, 61(6): 579-590, 2009
WOS关键词	MHC CLASS-I ; SIMIAN IMMUNODEFICIENCY VIRUS ; CRYSTAL-STRUCTURE ; INHIBITORY RECEPTOR ; COSTIMULATORY RECEPTOR ; ACTIVATING RECEPTOR ; IMMUNOGLOBULIN SUPERFAMILY ; MYELOMONOCYTIC CELLS ; CORECEPTOR FUNCTION ; PROGRAMMED DEATH-1
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
语种	英语
出版者	JOHN WILEY & SONS INC
WOS记录号	WOS:000266676400005
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2403089
专题	中国科学院大学
通讯作者	Gao, George F.
作者单位	1.Chinese Acad Sci, Key Lab Pathogen Microbiol & Immunol, Inst Microbiol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Coll Life Sci, Grad Univ, Beijing 100101, Peoples R China 3.Capital Med Univ, Dept Immunol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Chen, Yong,Shi, Yi,Cheng, Hao,et al. Structural immunology and crystallography help immunologists see the immune system in action: how t and nk cells touch their ligands[J]. Iubmb life,2009,61(6):579-590.
APA	Chen, Yong,Shi, Yi,Cheng, Hao,An, Yun-Qing,&Gao, George F..(2009).Structural immunology and crystallography help immunologists see the immune system in action: how t and nk cells touch their ligands.Iubmb life,61(6),579-590.
MLA	Chen, Yong,et al."Structural immunology and crystallography help immunologists see the immune system in action: how t and nk cells touch their ligands".Iubmb life 61.6(2009):579-590.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。