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	Metabolic profiles of serum from rats after subchronic exposure to chlorpyrifos and carbaryl
	Wang, Hui-Ping1,2; Liang, Yu-Jie1; Long, Ding-Xin1; Chen, Jia-Xiang1; Hou, Wei-Yuan1; Wu, Yi-Jun1
刊名	Chemical research in toxicology
	2009-06-01
卷号	22期号:6页码:1026-1033
ISSN号	0893-228X
DOI	10.1021/tx8004746
通讯作者	Wu, yi-jun(wuyj@ioz.ac.cn)
英文摘要	Chlorpyrifos (cpf) and carbaryl (car) have been widely used in agricultural and domestic settings. previous studies have demonstrated that cpf and car are generally neurotoxic to mammals, whereas the toxicities of these pesticides to other organs and their potential interactive effects remain unclear. the purpose of this study assessed the alterations of histopathology, biochemical parameters, and metabolic profiles of serum in rats following the treatment with cpf and car alone or in combination. no histopathological changes were observed in the liver and kidney tissues. biochemical analysis of blood showed that alanine aminotransferase and total bilirubin in serum increased slightly in cpf-treated rats as compared to controls. metabonomic analysis revealed alternations in a number of metabolites involving the metabolism of glucose, free fatty acids, and amino acids in liver mitochondria. the treatment of rats with cpf alone resulted in a decrease in lactate, low- and very low-density lipoprotein (ldl/vldl), dimethylglycine (dmg), and aspartate. this was accompanied by an increase in isoleucine and leucine, 3-hydroxybutyrate (3-hb), n-acetylglycoprotein (nac), acetone, succinate, glutamine, choline, creatine, glucose, and amino acids in a dose-dependent manner. similarly, treatment with a high dose of car alone led to a decrease in dmg, aspartate, ldl/vldl, and dimethylamine and an increase in taurine, glucose, and amino acids. the levels of lactate and ldl/vldl decreased, while those of 3-hb, nac, acetone, succinate, and glutamine elevated in the group of rats treated with a mixture of cpf and car as compared to the groups of cpf or car alone. our results suggest that subchronic exposure to cpf and car alone. or in combination, could cause a disturbance in energy and fatty acid metabolism in the liver mitochondria of rats. overall, we have shown that analysis of metabolic profiles can make exceptional contributions to the understanding of the individual or mutual effects following exposure to a low dose of pesticides.
WOS关键词	MAGNETIC-RESONANCE SPECTROSCOPY ; DEVELOPMENTAL NEUROTOXICITY ; INDUCED HEPATOTOXICITY ; H-1-NMR SPECTROSCOPY ; INTERACTIVE TOXICITY ; PATTERN-RECOGNITION ; NMR-SPECTROSCOPY ; BINARY-MIXTURE ; ADULT RATS ; METABONOMICS
WOS研究方向	Pharmacology & Pharmacy ; Chemistry ; Toxicology
WOS类目	Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Toxicology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000267020500008
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2401571
专题	中国科学院大学
通讯作者	Wu, Yi-Jun
作者单位	1.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Mol Toxicol Lab, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Wang, Hui-Ping,Liang, Yu-Jie,Long, Ding-Xin,et al. Metabolic profiles of serum from rats after subchronic exposure to chlorpyrifos and carbaryl[J]. Chemical research in toxicology,2009,22(6):1026-1033.
APA	Wang, Hui-Ping,Liang, Yu-Jie,Long, Ding-Xin,Chen, Jia-Xiang,Hou, Wei-Yuan,&Wu, Yi-Jun.(2009).Metabolic profiles of serum from rats after subchronic exposure to chlorpyrifos and carbaryl.Chemical research in toxicology,22(6),1026-1033.
MLA	Wang, Hui-Ping,et al."Metabolic profiles of serum from rats after subchronic exposure to chlorpyrifos and carbaryl".Chemical research in toxicology 22.6(2009):1026-1033.

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