| Dna photocleavage activity of cobalt(iii) polypyridyl complexes containing dpq ligand | |
| Sun, Yi1,2; Zhou, Qian-Xiong1; Chen, Jing-Rong1; Hou, Yuan-Jun1; Lei, Wan-Hua1; Wang, Xue-Song1; Zhang, Bao-Wen1 | |
| 刊名 | Journal of inorganic biochemistry
 |
| 2009-12-01 | |
| 卷号 | 103期号:12页码:1658-1665 |
| 关键词 | Cobalt(iii) complexes Dpq ligand Dna binding Dna photocleavage |
| ISSN号 | 0162-0134 |
| DOI | 10.1016/j.jinorgbio.2009.09.008 |
| 通讯作者 | Wang, xue-song(xswang@mail.ipc.ac.cn) |
| 英文摘要 | Four cobalt(iii) polypyridyl complexes, [co(phen)(3-n)(dpq)(n)](3+) (phen = 1,10-phenanthroline, dpq = dipyrido[3,2-f:2',3'-h]-quinoxaline) (n = 0, 1, 2, and 3) were synthesized and the influences of the dpq ligand on the photophysical properties, electrochemical properties, dna binding affinities, as well as photonuclease activities of the complexes, were examined in detail. the presence of dpq ligand increases the dna binding affinities of the corresponding complexes remarkably with respect to [co(phen)(3)](3+). with the sequential substitution of phen ligand by dpq ligand, the (1)o(2) quantum yields of the corresponding complexes are enhanced greatly. as a result, the photonuclease activities follow the order of [co(phen)(3)](3+) > [co(phen)(dpq)(2)](3+) > [co(phen)(2)(dpq)](3+) >> [co(phen)(3)](3+). it was found all the examined complexes can generate (center dot)oh upon uv irradiation, and (center dot)oh is also involved in dna photocleavage as reactive oxygen species. (c) 2009 elsevier inc. all rights reserved. |
| WOS关键词 | SINGLET OXYGEN ; RED-LIGHT ; CLEAVAGE ACTIVITY ; COPPER(II) COMPLEXES ; HETEROCYCLIC BASES ; VISIBLE-LIGHT ; MINOR-GROOVE ; IRON COMPLEX ; BINDING ; DIPYRIDOPHENAZINE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE INC |
| WOS记录号 | WOS:000271837800009 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2401269 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Xue-Song |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Photochem Convers & Optoelect Mat, Tech Inst Phys & Chem, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Yi,Zhou, Qian-Xiong,Chen, Jing-Rong,et al. Dna photocleavage activity of cobalt(iii) polypyridyl complexes containing dpq ligand[J]. Journal of inorganic biochemistry,2009,103(12):1658-1665. |
| APA | Sun, Yi.,Zhou, Qian-Xiong.,Chen, Jing-Rong.,Hou, Yuan-Jun.,Lei, Wan-Hua.,...&Zhang, Bao-Wen.(2009).Dna photocleavage activity of cobalt(iii) polypyridyl complexes containing dpq ligand.Journal of inorganic biochemistry,103(12),1658-1665. |
| MLA | Sun, Yi,et al."Dna photocleavage activity of cobalt(iii) polypyridyl complexes containing dpq ligand".Journal of inorganic biochemistry 103.12(2009):1658-1665. |
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