| Stabilizing parallel g-quadruplex dna by a new class of ligands: two non-planar alkaloids through interaction in lateral grooves | |
| Li, Qian1,3; Xiang, Junfeng1; Li, Xudong2; Chen, Lirong2; Xu, Xiaojie2; Tang, Yalin1; Zhou, Qiuju1,3; Li, Lin1,3; Zhang, Hong1; Sun, Hongxia1 | |
| 刊名 | Biochimie
 |
| 2009-07-01 | |
| 卷号 | 91期号:7页码:811-819 |
| 关键词 | G-quadruplex Groove binding Non-planar Alkaloids |
| ISSN号 | 0300-9084 |
| DOI | 10.1016/j.biochi.2009.03.007 |
| 通讯作者 | Tang, yalin(tangyl@iccas.ac.cn) |
| 英文摘要 | Human dna sequences consisting of tandem guanine (g) nucleotides can fold into a four-stranded structure named g-quadruplex via hoogsteen hydrogen bonding. as the sequences forming g-quadruplex exist in essential regions of eukaryotic chromosomes and are involved in many important biological processes, the study of their biological functions has currently become a hotspot. compounds selectively binding and stabilizing g-quadruplex structures have the potential to inhibit telomerase activity or alter oncogene expression levels and thus may act as antitumor agents. most of reported g-quadruplex ligands generally have planar structures which stabilize g-quadruplex by pi-pi stacking. however, based on a pharmacophore-based virtual screening two non-planar g-quadruplex ligands were found. these two ligands exhibit good capability for g-quadruplex stabilization and prefer binding to paralleled g-quadruplex rather than to duplex dna. the binding of these ligands to g-quadruplex may result from groove binding at a 2:1 stoichiometry. these results have shown that planar structures are not essential for g-quadruplex stabilizers, which may represent a new class of g-quadruplex-targeted agents as potential antitumor drugs. (c) 2009 elsevier masson sas. all rights reserved. |
| WOS关键词 | ANTICANCER DRUG DESIGN ; HUMAN TELOMERIC REPEAT ; ANTITUMOR AGENTS ; RECOGNITION ; NMR ; D(TTAGGGT)(4) ; INHIBITOR ; TARGETS ; POTENT ; DERIVATIVES |
| WOS研究方向 | Biochemistry & Molecular Biology |
| WOS类目 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| WOS记录号 | WOS:000267628700001 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2400318 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tang, Yalin |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci,BNLMS, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China 2.Peking Univ, BNLMS, State Key Lab Rare Earth Mat Chem & Applicat, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qian,Xiang, Junfeng,Li, Xudong,et al. Stabilizing parallel g-quadruplex dna by a new class of ligands: two non-planar alkaloids through interaction in lateral grooves[J]. Biochimie,2009,91(7):811-819. |
| APA | Li, Qian.,Xiang, Junfeng.,Li, Xudong.,Chen, Lirong.,Xu, Xiaojie.,...&Xu, Guangzhi.(2009).Stabilizing parallel g-quadruplex dna by a new class of ligands: two non-planar alkaloids through interaction in lateral grooves.Biochimie,91(7),811-819. |
| MLA | Li, Qian,et al."Stabilizing parallel g-quadruplex dna by a new class of ligands: two non-planar alkaloids through interaction in lateral grooves".Biochimie 91.7(2009):811-819. |
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