| Disruption of xct inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway | |
| Chen, R-S1,2,3; Song, Y-M4,5; Zhou, Z-Y1; Tong, T.4,5; Li, Y.1,2; Fu, M.4,5; Guo, X-L1,2; Dong, L-J4,5; He, X.1; Qiao, H-X1 | |
| 刊名 | Oncogene
 |
| 2009-01-29 | |
| 卷号 | 28期号:4页码:599-609 |
| 关键词 | Xct/slc7a11 Cancer Metastasis Caveolin-1 Beta-catenin Oxidative stress |
| ISSN号 | 0950-9232 |
| DOI | 10.1038/onc.2008.414 |
| 通讯作者 | Li, w.(wli@genetics.ac.cn) |
| 英文摘要 | Xct, the functional subunit of the cystine/glutamate transporter xc- system, plays a critical role in the maintenance of intracellular glutathione and redox balance. disruption of xct significantly inhibits the growth of a variety of carcinomas, including lymphoma, glioma, prostate and breast cancer. however, the role of xct in tumor metastasis remains largely unknown. in this study, both xct(+/+) and xct(-/-) melanocytes were used to evaluate the role of xct in adhesion. xct activity was suppressed by an inhibitor, sulfasalazine (sasp), or by xct sirna in an esophageal cancer cell line, kyse150. we found that disruption of xct enhanced homotypic cell-cell adhesion and attenuated cell-extracellular matrix adhesion. sasp significantly inhibited both cell invasion of kyse150 in vitro and its experimental metastasis in nude mice. caveolin-1 was upregulated and beta-catenin was recruited to the plasma membrane when xct was deficient, which were followed by the inhibition of beta-catenin transcriptional activity. further study revealed that the upregulation of caveolin-1 and inhibition of tumor cell invasion were mediated by reactive oxygen species-induced p38 mapk activation. these results first establish the role of xct in tumor metastasis and implicate a potential target for cancer therapy. |
| WOS关键词 | BETA-CATENIN ; DOWN-REGULATION ; PREMATURE SENESCENCE ; TYROSINE KINASES ; OXIDATIVE STRESS ; PLASMA-MEMBRANE ; CYSTINE UPTAKE ; E-CADHERIN ; CAVEOLIN-1 ; PROTEIN |
| WOS研究方向 | Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity |
| WOS类目 | Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000262866500013 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2398920 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li, W. |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol & Dev Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China 3.Fujian Acad Agr Sci, Ctr Biotechnol, Fuzhou, Fujian, Peoples R China 4.Peking Union Med Coll, Canc Inst Hosp, State Key Lab Mol Oncol, Beijing 100021, Peoples R China 5.Chinese Acad Med Sci, Beijing 100037, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, R-S,Song, Y-M,Zhou, Z-Y,et al. Disruption of xct inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway[J]. Oncogene,2009,28(4):599-609. |
| APA | Chen, R-S.,Song, Y-M.,Zhou, Z-Y.,Tong, T..,Li, Y..,...&Li, W..(2009).Disruption of xct inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway.Oncogene,28(4),599-609. |
| MLA | Chen, R-S,et al."Disruption of xct inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway".Oncogene 28.4(2009):599-609. |
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