| The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits leukocyte activation by bacterial formylpeptide through the receptor fpr | |
| Zhu, Jingjing1; Wang, Oumei1,2; Ruan, Lingfei1,2; Hou, Xinwei1,2; Cui, Youhong1; Wang, Ji Ming3; Le, Yingying1,2 | |
| 刊名 | International immunopharmacology
 |
| 2009-08-01 | |
| 卷号 | 9期号:9页码:1126-1130 |
| 关键词 | Egcg Leukocyte Fmlf Inflammation Calcium mobilization Map kinase |
| ISSN号 | 1567-5769 |
| DOI | 10.1016/j.intimp.2009.05.002 |
| 通讯作者 | Le, yingying(yyle@sibs.ac.cn) |
| 英文摘要 | Although green tea polyphenol catechin is considered as a potential anti-inflammatory agent, its effect on bacterial component-induced inflammation has been poorly investigated. we examined the capacity of epigallocatechin gallate (egcg) to regulate leukocyte responses to bacterial chemotactic peptide n-formylmethionyl-leucyl-phenylalanine (fmlf), which is recognized by a human g protein-coupled receptor fpr on phagocytic leukocytes. pretreatment of human monocytic cells or fpr-transfected rat basophilic leukemia cells (etfr cells) with egcg significantly inhibited fmlf-induced chemotaxis. intraperitoneal administration of egcg in mice suppressed fmlf-induced leukocyte infiltration into the air pouch created in the skin. mechanistic studies revealed that egcg dose-dependently suppressed fmlf-induced calcium flux in monocytic cells and etfr cells. fmlf-induced etfr cell migration was significantly inhibited by a specific mek1/2 inhibitor, pd98059, which was associated with reduction in fmlf-induced erk1/2 phosphorylation. these results suggest that egcg inhibits fpr-mediated leukocyte activation thus is a promising anti-inflammatory compound. (c) 2009 elsevier b.v. all rights reserved. |
| WOS关键词 | CHEMOKINE RECEPTORS ; MURINE MODEL ; IN-VIVO ; INFLAMMATION ; CHEMOTAXIS ; NEUTROPHIL ; CATECHINS ; GALLATE ; IDENTIFICATION ; DEGRANULATION |
| WOS研究方向 | Immunology ; Pharmacology & Pharmacy |
| WOS类目 | Immunology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000268360800016 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2395314 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Le, Yingying |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China 3.NCI, Mol Immunoregulat Lab, Ctr Canc Res, Frederick, MD 21701 USA |
| 推荐引用方式 GB/T 7714 | Zhu, Jingjing,Wang, Oumei,Ruan, Lingfei,et al. The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits leukocyte activation by bacterial formylpeptide through the receptor fpr[J]. International immunopharmacology,2009,9(9):1126-1130. |
| APA | Zhu, Jingjing.,Wang, Oumei.,Ruan, Lingfei.,Hou, Xinwei.,Cui, Youhong.,...&Le, Yingying.(2009).The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits leukocyte activation by bacterial formylpeptide through the receptor fpr.International immunopharmacology,9(9),1126-1130. |
| MLA | Zhu, Jingjing,et al."The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits leukocyte activation by bacterial formylpeptide through the receptor fpr".International immunopharmacology 9.9(2009):1126-1130. |
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