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	Chloro-substituted dipicolinate vanadium complexes: synthesis, solution, solid-state, and insulin-enhancing properties
	Smee, Jason J.2; Epps, Jason A.1; Ooms, Kristopher3; Bolte, Stephanie E.3; Polenova, Tatyana3; Baruah, Bharat1; Yang, Luqin1; Ding, Wenjun4; Li, Ming4; Willsky, Gail R.5
刊名	Journal of inorganic biochemistry
	2009-04-01
卷号	103期号:4页码:575-584
关键词	Vanadium complexes Chlorodipicolinate Dipicolinate 4-chloro-2,6-dicarboxypyridine (51)v nmr spectroscopy Solid-state nmr Electronic structure Isotropic Anisotropy Electric field gradient tensor Insulin-enhancing
ISSN号	0162-0134
DOI	10.1016/j.jinorgbio.2008.12.015
通讯作者	Crans, debbie c.(crans@lamar.colostate.edu)
英文摘要	Three vanadium complexes of chlorodipicolinic acid (4-chloro-2,6-dipicolinic acid) in oxidation states iii iv, and v were prepared and their properties characterized across the oxidation states. in addition, the series of hydroxylamido, methylhydroxylamido, dimethylhydroxylamido, and diethylhydroxylamido complexes were prepared from the chlorodipicolinato dioxovanadium(v) complex. the vanadium(v) compounds were characterized in solution by (51)v and (1)h nmr and in the solid-state by x-ray diffraction and (51)v nmr. density functional theory (dft) calculations were performed to evaluate the experimental parameters and further describes the electronic structure of the complex. the small structural changes that do occur in bond lengths and angles and partial charges on different atoms are minor compared to the charge features that are responsible for the majority of the electric field gradient tensor. the epr parameters of the vanadium(iv) complex were characterized and compared to the corresponding dipicolinate complex. the chemical properties of the chlorodipicolinate compounds are discussed and correlated with their insulin-enhancing activity in streptozoticin (stz) induced diabetic wistar rats. the effect of the chloro-substitution on lowering diabetic hyperglycemia was evaluated and differences were found depending on the compounds oxidation state similar as was observed for the vanadium ill. iv and v dipicolinate complexes (p. buglyo, d.c. crans, e.m. nagy, r.l. lindo, l. yang, j.j. smee, w. jin, l-h. chi, m.e. godzala iii, g.r. willsky, inorg. chem. 44 (2005) 5416-5427). however, a linear correlation of oxidation states with efficacy was not observed, which suggests that the differences in mode of action are not simply ail issue of redox equivalents. importantly, our results contrast the previous observation with the vanadium-picolinate complexes, where the halogen substituents increased the insulin-enhancing properties of the complex (t. takino, h. yasui, a. yoshitake, y. hamajima, r. matsushita, j. takada, h. sakurai, j. biol. inorg. chem. 6 (2001) 133-142). published by elsevier inc.
WOS关键词	AQUEOUS CHEMISTRY ; NMR-SPECTROSCOPY ; OXIDATION-STATES ; IN-VITRO ; V-51 NMR ; DENSITY ; SYSTEMS ; ACID ; RATS ; BIS(MALTOLATO)OXOVANADIUM(IV)
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000264904400014
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2393788
专题	中国科学院大学
通讯作者	Crans, Debbie C.
作者单位	1.Colorado State Univ, Dept Chem, Ft Collins, CO 80513 USA 2.Univ Texas Tyler, Dept Chem, Tyler, TX 75799 USA 3.Univ Delaware, Dept Chem & Biochem, Brown Labs 036, Newark, DE 19716 USA 4.Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing 100049, Peoples R China 5.SUNY Buffalo, Dept Biochem, Sch Med & Biomed Sci, Buffalo, NY 14214 USA
推荐引用方式 GB/T 7714	Smee, Jason J.,Epps, Jason A.,Ooms, Kristopher,et al. Chloro-substituted dipicolinate vanadium complexes: synthesis, solution, solid-state, and insulin-enhancing properties[J]. Journal of inorganic biochemistry,2009,103(4):575-584.
APA	Smee, Jason J..,Epps, Jason A..,Ooms, Kristopher.,Bolte, Stephanie E..,Polenova, Tatyana.,...&Crans, Debbie C..(2009).Chloro-substituted dipicolinate vanadium complexes: synthesis, solution, solid-state, and insulin-enhancing properties.Journal of inorganic biochemistry,103(4),575-584.
MLA	Smee, Jason J.,et al."Chloro-substituted dipicolinate vanadium complexes: synthesis, solution, solid-state, and insulin-enhancing properties".Journal of inorganic biochemistry 103.4(2009):575-584.

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