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	Characterization of synthetic heparin-like compounds by negative electrospray ionization fourier transform ion cyclotron resonance mass spectrometry
	Yan Cun-Yu1,2; Yu Biao3; Liu Shu-Ying1; Cui Meng1; Song Feng-Rui1; Liu Zhi-Qiang1
刊名	Chinese journal of analytical chemistry
	2008-07-01
卷号	36期号:7页码:910-914
关键词	Fourier transform ion cyclotron resonance mass spectrometry(ft-icr-ms) Heparin Electrosray Tandem mass spectrometry Sustained off-resonance irradiation collision induced dissociation
ISSN号	0253-3820
通讯作者	Liu shu-ying(mslab@ciac.jl.cn)
英文摘要	The full scan and sustained off-resonance it-radiation collision induced dissociation (sori-cid) techniques were employed to study three synthetic heparin-like compounds dh alpha, th alpha and th beta in negative mode using electrospray ionization fourier transform ion cyclotron resonance mass spectrometry (esi fticr-ms). the concentration of stock solution was 10 mu mol/l. the stock solutions were introduced into the ft-icr-ms by syringe pump directly. the structure of sulfamin and sulfonate inside the heparin-like compounds can undergo one or more neutral losses of so, under the soft electrospray ionization condition. the single and double charged pseudomolecular ions presented in the full scan spectra of these compounds. some double charged pseudomolecular ions produced single or double charged fragments, which were deduced from the isotope profile of product ions. the fragmentation pathways of selected precursor ions were assigned by combining the ultrahigh measurement accuracy of their fticr ms data and fragments' charge. the mean errors of the measured mass to charge ratios were less than 3.0 x 10(-6). the results provide references for the analysis of complex heparin-like compounds by mass spectrometry.
WOS关键词	SPECTRA
WOS研究方向	Chemistry
WOS类目	Chemistry, Analytical
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000258939700009
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2386993
专题	中国科学院大学
通讯作者	Liu Shu-Ying
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun Ctr Mass Spectrometry, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Yan Cun-Yu,Yu Biao,Liu Shu-Ying,et al. Characterization of synthetic heparin-like compounds by negative electrospray ionization fourier transform ion cyclotron resonance mass spectrometry[J]. Chinese journal of analytical chemistry,2008,36(7):910-914.
APA	Yan Cun-Yu,Yu Biao,Liu Shu-Ying,Cui Meng,Song Feng-Rui,&Liu Zhi-Qiang.(2008).Characterization of synthetic heparin-like compounds by negative electrospray ionization fourier transform ion cyclotron resonance mass spectrometry.Chinese journal of analytical chemistry,36(7),910-914.
MLA	Yan Cun-Yu,et al."Characterization of synthetic heparin-like compounds by negative electrospray ionization fourier transform ion cyclotron resonance mass spectrometry".Chinese journal of analytical chemistry 36.7(2008):910-914.

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