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	Heregulin beta activates store-operated ca2+ channels through c-erbb2 receptor level-dependent pathway in human breast cancer cells
	Liao, Jie-Ying; Li, Lin-Lin; Wei, Qun; Yue, Jia-Chang
刊名	Archives of biochemistry and biophysics
	2007-02-15
卷号	458期号:2页码:244-252
关键词	Hrg beta Store-operated ca2+ channel (soc) C-erbb2 Plc Human breast cancer cells
ISSN号	0003-9861
DOI	10.1016/j.abb.2006.12.003
通讯作者	Yue, jia-chang(yueje@sun5.ibp.ac.cn)
英文摘要	The heregulin beta (hrg beta) is a ligand to activate c-erbb2/c-erbb3 interaction and can subsequently increases cytosolic [ca2+](i). in the two human breast cancer cell lines, mcf-7 shows a low c-erbb2 expression level, whereas sk-br-3 overexpress c-erbb2 receptor. in this article, we have found that in mcf-7, hrg beta induced ca2+ release from the endoplasmic reticulums (er) and subsequently activated ca2+ entry via store-operated ca2+ channel (soc). however, in sk-br-3, hrg beta failed to induce ca2+ release and ca2+ entry. rna interference to decrease c-erbb2 level in sk-br-3 resulted in reactivation of hrg beta-evoked ca2+ release and ca2+ entry via soc, which was similar to that of mcf-7. in addition, in the absence of hrg beta, a constitutive activation of soc was observed in sk-br-3 rather than in mcf-7 and c-erbb2-sirna treated sk-br-3. compared to the cells with low c-erbb2 level, c-erbb2 might tend to interact with c-erbb3 in the resting state in the cells with high c-erbb2 level, which resulted in different [ca2+](i) responses to hrg beta. in sk-br-3, the ca2+ mobilization in the presence or in the absence of hrg beta was completely blocked by plc inhibitor u73122. in summary, our results indicate that hrg beta-induced soc was regulated by c-erbb2 level and dependent on activation of plc in human breast cancer cells. (c) 2006 elsevier inc. all rights reserved.
WOS关键词	EPIDERMAL-GROWTH-FACTOR ; CAPACITATIVE CALCIUM-ENTRY ; SIGNAL-TRANSDUCTION ; CARCINOMA CELLS ; HUMAN-PLATELETS ; EXCITABILITY ; COEXPRESSION ; INHIBITION ; RETICULUM ; MEMBRANE
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000244385000019
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2380892
专题	中国科学院大学
通讯作者	Yue, Jia-Chang
作者单位	1.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Beijing Normal Univ, Sch Life Sci, Beijing 100875, Peoples R China
推荐引用方式 GB/T 7714	Liao, Jie-Ying,Li, Lin-Lin,Wei, Qun,et al. Heregulin beta activates store-operated ca2+ channels through c-erbb2 receptor level-dependent pathway in human breast cancer cells[J]. Archives of biochemistry and biophysics,2007,458(2):244-252.
APA	Liao, Jie-Ying,Li, Lin-Lin,Wei, Qun,&Yue, Jia-Chang.(2007).Heregulin beta activates store-operated ca2+ channels through c-erbb2 receptor level-dependent pathway in human breast cancer cells.Archives of biochemistry and biophysics,458(2),244-252.
MLA	Liao, Jie-Ying,et al."Heregulin beta activates store-operated ca2+ channels through c-erbb2 receptor level-dependent pathway in human breast cancer cells".Archives of biochemistry and biophysics 458.2(2007):244-252.

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