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	Olfactory ensheathing cell apoptosis induced by hypoxia and serum deprivation
	Zhao, Yanhong; Wang, Bin; Gao, Yuan; Zhao, Yannan; Xiao, Zhifeng; Zhao, Wenxue; Chen, Bing; Wang, Xia; Dai, Jianwu
刊名	Neuroscience letters
	2007-06-29
卷号	421期号:3页码:197-202
关键词	Oecs Apoptosis Caspase Mitochondria P53 Ischemia
ISSN号	0304-3940
DOI	10.1016/j.neulet.2007.04.028
通讯作者	Dai, jianwu(jwdai@genetics.ac.cn)
英文摘要	Olfactory ensheathing cell (oec) transplantation is one promising technology for the treatment of spinal cord injury. many studies have been focusing on the functional improvement after oec implantation in spinal cord injury of animals. however, little is known about the mechanisms about how oecs respond to the proapoptotic microenviromnent after transplantation. we use the hypoxia and serum deprivation (hsd) paradigm in oecs to evaluate the effects of the ischemic damage. oecs underwent caspase-dependent apoptosis during hsd and a pan-caspase inhibitor specifically blocked the cell death. in addition, hsd resulted in a time-dependent decrease. of mitochondrial membrane potential delta psi(m) triggering a transient increase in p53 content and activated p53 in a time-dependent manner. in summary, our data suggest that hsd trigger apoptotic oecs death. which may be related to mitochondria dysfunction and the dependence of p53. (c) 2007 elsevier ireland ltd. all rights reserved.
WOS关键词	SPINAL-CORD-INJURY ; FUNCTIONAL RECOVERY ; CYTOCHROME-C ; P53 PROTEIN ; GLIA ; DEATH ; REGENERATION ; RATS ; MITOCHONDRIA ; EXPRESSION
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000248152100003
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2380210
专题	中国科学院大学
通讯作者	Dai, Jianwu
作者单位	1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Yanhong,Wang, Bin,Gao, Yuan,et al. Olfactory ensheathing cell apoptosis induced by hypoxia and serum deprivation[J]. Neuroscience letters,2007,421(3):197-202.
APA	Zhao, Yanhong.,Wang, Bin.,Gao, Yuan.,Zhao, Yannan.,Xiao, Zhifeng.,...&Dai, Jianwu.(2007).Olfactory ensheathing cell apoptosis induced by hypoxia and serum deprivation.Neuroscience letters,421(3),197-202.
MLA	Zhao, Yanhong,et al."Olfactory ensheathing cell apoptosis induced by hypoxia and serum deprivation".Neuroscience letters 421.3(2007):197-202.

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