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	Trimeric structure of the wild soluble chloride intracellular ion channel clic4 observed in crystals
	Li, YF; Li, DF; Zeng, ZH; Wang, DC
刊名	Biochemical and biophysical research communications
	2006-05-19
卷号	343期号:4页码:1272-1278
关键词	Chloride intracellular ion channel Clic4 Crystal structure Trimeric structure
ISSN号	0006-291X
DOI	10.1016/j.bbrc.2006.03.099
通讯作者	Wang, dc()
英文摘要	The crystal structure of a wild type of the human soluble chloride intracellular ion channel clic4 (wclic4) has been determined at a resolution of 2.2 angstrom. the structure shows a homotrimer in an asymmetric unit, which is first observed in clics. the assembly of the trimer takes a unique triple interaction mode between three monomers with a hydrogen-bond network and hydrophobic contacts. through such complicated interactions, the homotrimer of wclic4 is firmly stabilized. the structure shows an oligomeric mode with a unique assembly mechanism by which the oligomerization of clic4 can be performed without any intramolecular disulfide bond formation. it indicated a possibility that clic4 may take a unique structural organization distinct from clic1 for docking with lipid bilayers. in addition, the structure shows distinct conformational states of the h2 region for respective monomers of the trimer, which reveal an intrinsic conformational susceptibility for this significant region in the structural transition. (c) 2006 elsevier inc. all rights reserved.
WOS关键词	MOLECULAR-CLONING ; PROTEIN ; EXPRESSION ; MEMBER ; FAMILY ; NCC27 ; GENE ; FORM ; P64
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000237269000041
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2379659
专题	中国科学院大学
通讯作者	Wang, DC
作者单位	1.Chinese Acad Sci, Natl Lab Biomacromol, Inst Biophys, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Li, YF,Li, DF,Zeng, ZH,et al. Trimeric structure of the wild soluble chloride intracellular ion channel clic4 observed in crystals[J]. Biochemical and biophysical research communications,2006,343(4):1272-1278.
APA	Li, YF,Li, DF,Zeng, ZH,&Wang, DC.(2006).Trimeric structure of the wild soluble chloride intracellular ion channel clic4 observed in crystals.Biochemical and biophysical research communications,343(4),1272-1278.
MLA	Li, YF,et al."Trimeric structure of the wild soluble chloride intracellular ion channel clic4 observed in crystals".Biochemical and biophysical research communications 343.4(2006):1272-1278.

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