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	Inhibitory effect of epimedium extract on s-adenosyl-l-homocysteine hydrolase and biomethylation
	Zhang, XY; Li, YJ; Yang, XD; Wang, K; Ni, JZ; Qu, XG
刊名	Life sciences
	2005-11-26
卷号	78期号:2页码:180-186
关键词	Epimedium extract S-adenosyl-l-homocysteine hydrolase Biomethylation
ISSN号	0024-3205
DOI	10.1016/j.lfs.2005.04.057
通讯作者	Ni, jz()
英文摘要	In the present paper, the inhibitory effect of epimedium extract on the activity of s-adenosyl-l-homocysteine (adohcy) hydrolase was studied. the results showed that epimedium extract inhibited the activity of recombinant human adohcy hydrolase in a dose-dependent manner. this inhibitory effect was also observed in hepatic cell line 7701 and hepatoma hepg2, however, the effect in 7701 cells was more potent than in hepg2 cells. the extract could significantly reduce adomet/adohcy ratio in 7701 cells in a dose-dependent manner, suggesting reduced biomethylation level in 7701 cells. in contrast, it resulted in elevated adomet/adohcy ratio in the hepg2 cells. the result of maldi-ms assay indicated that epimedin a and ikarisoside f from the extract could bind to adohcy hydrolase. the present data suggested that epimedium extract could inhibit the activity of adohcy hydrolase, thus regulating the cellular biomethylation as well as reducing cellular hcy level. these results will provide new clues to the mechanisms of epimedium in curing of cardiovascular disease and regulating tumor cell growth. (c) 2005 elsevier inc. all rights reserved.
WOS关键词	ADENOSYLHOMOCYSTEINE HYDROLASE ; TRANSPORT ACTIVITY ; HUMAN-FIBROBLASTS ; ADENOSYLMETHIONINE ; TRANSMETHYLATIONS ; INDUCTION ; DISEASE ; CYSTINE ; BINDING ; FOLATE
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS类目	Medicine, Research & Experimental ; Pharmacology & Pharmacy
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000233187400009
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2378334
专题	中国科学院大学
通讯作者	Ni, JZ
作者单位	1.Chinese Acad Sci, Grad Sch, Changchun Inst Appl Chem, Changchun 130022, Peoples R China 2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China 3.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Natl Res Labs Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式 GB/T 7714	Zhang, XY,Li, YJ,Yang, XD,et al. Inhibitory effect of epimedium extract on s-adenosyl-l-homocysteine hydrolase and biomethylation[J]. Life sciences,2005,78(2):180-186.
APA	Zhang, XY,Li, YJ,Yang, XD,Wang, K,Ni, JZ,&Qu, XG.(2005).Inhibitory effect of epimedium extract on s-adenosyl-l-homocysteine hydrolase and biomethylation.Life sciences,78(2),180-186.
MLA	Zhang, XY,et al."Inhibitory effect of epimedium extract on s-adenosyl-l-homocysteine hydrolase and biomethylation".Life sciences 78.2(2005):180-186.

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