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	A novel domain-based method for predicting the functional classes of proteins
	Yu, XJ; Lin, JC; Shi, TL; Li, YX
刊名	Chinese science bulletin
	2004-11-01
卷号	49期号:22页码:2379-2384
关键词	Protein function prediction Maximum likelihood estimation Expectation maximization Domain
ISSN号	1001-6538
DOI	10.1360/982004-142
通讯作者	Li, yx()
英文摘要	Prediction of protein functions from known genomic sequences is an important mission of bioinformatics. one approach is to classify proteins into functional categories. we have therefore developed a method based on protein domain composition and the maximum likelihood estimation (mle) algorithm to classify proteins according to functions. using the saccharomyces cerevisiae genome, we compared the effectiveness of the mle approach with that of an intuitive and simple method. the mle method outperformed the simple method, achieving an estimated specificity of 75.45% and an estimated sensitivity of 40.26%. these results indicate that domain is an important feature of proteins and is closely related to protein function.
WOS关键词	SEQUENCE ; GENOMES ; GENES ; CLASSIFICATION ; ALGORITHM ; PROFILES ; DATABASE ; PFAM
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	SCIENCE CHINA PRESS
WOS记录号	WOS:000226823300008
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376931
专题	中国科学院大学
通讯作者	Li, YX
作者单位	Chinese Acad Sci, Grad Sch, Bioinformat Ctr, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Yu, XJ,Lin, JC,Shi, TL,et al. A novel domain-based method for predicting the functional classes of proteins[J]. Chinese science bulletin,2004,49(22):2379-2384.
APA	Yu, XJ,Lin, JC,Shi, TL,&Li, YX.(2004).A novel domain-based method for predicting the functional classes of proteins.Chinese science bulletin,49(22),2379-2384.
MLA	Yu, XJ,et al."A novel domain-based method for predicting the functional classes of proteins".Chinese science bulletin 49.22(2004):2379-2384.

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