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	The arabidopsis transcription factor brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1 is a direct substrate of mitogen-activated protein kinase6 and regulates immunity
	Kang, Sining1; Yang, Fan1,2; Li, Lin3; Chen, Huamin4; Chen, She3; Zhang, Jie1
刊名	Plant physiology
	2015-03-01
卷号	167期号:3页码:1076-+
ISSN号	0032-0889
DOI	10.1104/pp.114.250985
通讯作者	Zhang, jie(zhangjie@im.ac.cn)
英文摘要	Pathogen-associated molecular patterns (pamps) are recognized by plant pattern recognition receptors to activate pamp-triggered immunity (pti). mitogen-activated protein kinases (mapks), as well as other cytoplasmic kinases, integrate upstream immune signals and, in turn, dissect pti signaling via different substrates to regulate defense responses. however, only a few direct substrates of these signaling kinases have been identified. here, we show that pamp perception enhances phosphorylation of brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1 (bes1), a transcription factor involved in brassinosteroid (br) signaling pathway, through pathogen-induced mapks in arabidopsis (arabidopsis thaliana). bes1 interacts with mitogen-activated protein kinase6 (mpk6) and is phosphorylated by mpk6. bes1 loss-of-function mutants display compromised resistance to bacterial pathogen pseudomonas syringae pv tomato dc3000. bes1 s286a/s137a double mutation (bes1(ssaa)) impairs pamp-induced phosphorylation and fails to restore bacterial resistance in bes1 mutant, indicating a positive role of bes1 phosphorylation in plant immunity. bes1 is phosphorylated by glycogen synthase kinase3 (gsk3)-like kinase br-insensitive2 (bin2), a negative regulator of br signaling. br perception inhibits bin2 activity, allowing dephosphorylation of bes1 to regulate plant development. however, bes1(ssaa) does not affect br-mediated plant growth, suggesting differential residue requirements for the modulation of bes1 phosphorylation in pti and br signaling. our study identifies bes1 as a unique direct substrate of mpk6 in pti signaling. this finding reveals mapk-mediated bes1 phosphorylation as another bes1 modulation mechanism in plant cell signaling, in addition to gsk3-like kinase-mediated bes1 phosphorylation and f box protein-mediated bes1 degradation.
WOS关键词	PLANT INNATE IMMUNITY ; PSEUDOMONAS-SYRINGAE EFFECTOR ; GENE-EXPRESSION ; SIGNAL-TRANSDUCTION ; TRIGGERED IMMUNITY ; CYTOPLASMIC KINASE ; RECEPTOR FLS2 ; FLAGELLIN ; THALIANA ; DEFENSE
WOS研究方向	Plant Sciences
WOS类目	Plant Sciences
语种	英语
出版者	AMER SOC PLANT BIOLOGISTS
WOS记录号	WOS:000354413900036
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376540
专题	中国科学院大学
通讯作者	Zhang, Jie
作者单位	1.Chinese Acad Sci, Inst Microbiol, State Key Lab Plant Genom, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Natl Inst Biol Sci, Beijing 102206, Peoples R China 4.Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China
推荐引用方式 GB/T 7714	Kang, Sining,Yang, Fan,Li, Lin,et al. The arabidopsis transcription factor brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1 is a direct substrate of mitogen-activated protein kinase6 and regulates immunity[J]. Plant physiology,2015,167(3):1076-+.
APA	Kang, Sining,Yang, Fan,Li, Lin,Chen, Huamin,Chen, She,&Zhang, Jie.(2015).The arabidopsis transcription factor brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1 is a direct substrate of mitogen-activated protein kinase6 and regulates immunity.Plant physiology,167(3),1076-+.
MLA	Kang, Sining,et al."The arabidopsis transcription factor brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1 is a direct substrate of mitogen-activated protein kinase6 and regulates immunity".Plant physiology 167.3(2015):1076-+.

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