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	Iodothyronine deiodinase gene analysis of the pacific oyster crassostrea gigas reveals possible conservation of thyroid hormone feedback regulation mechanism in mollusks
	Huang Wen1,2; Xu Fei1; Qu Tao1; Li Li1; Que Huayong1; Zhang Guofan1
刊名	Chinese journal of oceanology and limnology
	2015-07-01
卷号	33期号:4页码:997-1006
关键词	Iodothyronine deiodinase Crassostrea gigas Thyroid hormone (th) Clone Expression analysis
ISSN号	0254-4059
DOI	10.1007/s00343-015-4300-x
通讯作者	Que huayong(hque@qdio.ac.cn)
英文摘要	Iodothyronine deiodinase catalyzes the initiation and termination of thyroid hormones (ths) effects, and plays a central role in the regulation of thyroid hormone level in vertebrates. in non-chordate invertebrates, only one deiodinase has been identified in the scallop chlamys farreri. here, two deiodinases were cloned in the pacific oyster crassostrea gigas (cgdx and cgdy). the characteristic in-frame tga codons and selenocysteine insertion sequence elements in the oyster deiodinase cdnas supported the activity of them. furthermore, seven orthologs of deiodinases were found by a tblastn search in the mollusk lottia gigantea and the annelid capitella teleta. a phylogenetic analysis revealed that the deiodinase gene originated from an common ancestor and a clade-specific gene duplication occurred independently during the differentiation of the mollusk, annelid, and vertebrate lineages. the distinct spatiotemporal expression patterns implied functional divergence of the two deiodinases. the expression of cgdx and cgdy was influenced by l-thyroxine t4, and putative thyroid hormone responsive elements were found in their promoters, which suggested that the oyster deiodinases were feedback regulated by th. epinephrine stimulated the expression level of cgdx and cgdy, suggesting an interaction effect between different hormones. this study provides the first evidence for the existence of a conserved th feedback regulation mechanism in mollusks, providing insights into th evolution.
WOS关键词	SECIS ELEMENTS ; METAMORPHOSIS ; EXPRESSION ; INDUCTION ; RECEPTOR ; MODEL
WOS研究方向	Marine & Freshwater Biology ; Oceanography
WOS类目	Limnology ; Oceanography
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000357037100021
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376424
专题	中国科学院大学
通讯作者	Que Huayong
作者单位	1.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Huang Wen,Xu Fei,Qu Tao,et al. Iodothyronine deiodinase gene analysis of the pacific oyster crassostrea gigas reveals possible conservation of thyroid hormone feedback regulation mechanism in mollusks[J]. Chinese journal of oceanology and limnology,2015,33(4):997-1006.
APA	Huang Wen,Xu Fei,Qu Tao,Li Li,Que Huayong,&Zhang Guofan.(2015).Iodothyronine deiodinase gene analysis of the pacific oyster crassostrea gigas reveals possible conservation of thyroid hormone feedback regulation mechanism in mollusks.Chinese journal of oceanology and limnology,33(4),997-1006.
MLA	Huang Wen,et al."Iodothyronine deiodinase gene analysis of the pacific oyster crassostrea gigas reveals possible conservation of thyroid hormone feedback regulation mechanism in mollusks".Chinese journal of oceanology and limnology 33.4(2015):997-1006.

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