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	Tegument protein orf45 plays an essential role in virion morphogenesis of murine gammaherpesvirus 68
	Jia, Xing1,2; Shen, Sheng1; Lv, Ying1,2; Zhang, Ziwei1,2; Guo, Haitao1; Deng, Hongyu1,3
刊名	Journal of virology
	2016-08-01
卷号	90期号:16页码:7587-7592
ISSN号	0022-538X
DOI	10.1128/jvi.03231-15
通讯作者	Deng, hongyu(hydeng@moon.ibp.ac.cn)
英文摘要	Tegument proteins play critical roles in herpesvirus morphogenesis. orf45 is a conserved tegument protein of gammaherpes-viruses; however, its role in virion morphogenesis is largely unknown. in this work, we determined the ultrastructural localization of murine gammaherpesvirus 68 (mhv-68) orf45 and found that this protein was incorporated into virions around the site of host-derived vesicles. notably, the absence of orf45 inhibited nucleocapsid egress and blocked cytoplasmic virion maturation, demonstrating that orf45 is essential for mhv-68 virion morphogenesis.
WOS关键词	SARCOMA-ASSOCIATED HERPESVIRUS ; SECONDARY ENVELOPMENT ; EGRESS ; PHOSPHORYLATION ; IDENTIFICATION ; REPLICATION ; INTERFERON ; ORF33 ; ORF52 ; CELLS
WOS研究方向	Virology
WOS类目	Virology
语种	英语
出版者	AMER SOC MICROBIOLOGY
WOS记录号	WOS:000382306500045
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376336
专题	中国科学院大学
通讯作者	Deng, Hongyu
作者单位	1.Chinese Acad Sci, Key Lab Infect & Immun, Inst Biophys, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Jia, Xing,Shen, Sheng,Lv, Ying,et al. Tegument protein orf45 plays an essential role in virion morphogenesis of murine gammaherpesvirus 68[J]. Journal of virology,2016,90(16):7587-7592.
APA	Jia, Xing,Shen, Sheng,Lv, Ying,Zhang, Ziwei,Guo, Haitao,&Deng, Hongyu.(2016).Tegument protein orf45 plays an essential role in virion morphogenesis of murine gammaherpesvirus 68.Journal of virology,90(16),7587-7592.
MLA	Jia, Xing,et al."Tegument protein orf45 plays an essential role in virion morphogenesis of murine gammaherpesvirus 68".Journal of virology 90.16(2016):7587-7592.

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