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	Tfeb regulates per3 expression via glucose-dependent effects on clock/bmal1
	Luo, Wenwen; Ma, Shumin; Yang, Yunzhi; Wang, Chenyao; Zhang, Deyi; Zhang, Qian; Liu, Yi; Liu, Zhixue
刊名	International journal of biochemistry & cell biology
	2016-09-01
卷号	78页码:31-42
关键词	Tfeb Per3 Clock Bmal1 Circadian rhythm
ISSN号	1357-2725
DOI	10.1016/j.biocel.2016.06.020
通讯作者	Liu, zhixue(zxliu@sibs.ac.cn)
英文摘要	It has been reported that metabolites regulate circadian rhythms through direct effects on clock genes. a metabolic network involving per3 raises the possibility that some metabolic regulators are directly involved in the mammalian clock. here, we show that the bhlh family transcription factor tfeb regulates per3 through the clock/bmal1 complex. in the liver, tfeb expression displays circadian rhythms. a loss of tfeb function disrupts and dampens the expression of per3 but not the expression of other circadian genes, such as per1, per2, cry1 and cry2. tfeb physically interacts with clock/bmal1 through its n-terminal region. in the presence of tfeb, bmal1/clock-mediated transcription is enhanced. moreover, the tfeb/clock/bmal1 complex is regulated by glucose. these results show that tfeb has a role in the mammalian clock mechanism. (c) 2016 published by elsevier ltd.
WOS关键词	HIGH-FAT DIET ; CIRCADIAN CLOCK ; LYSOSOMAL BIOGENESIS ; GENE-EXPRESSION ; FEEDBACK LOOP ; TRANSCRIPTION ; METABOLISM ; ORGANIZATION ; CLOCK-BMAL1 ; COMPONENTS
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000383297300004
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376308
专题	中国科学院大学
通讯作者	Liu, Zhixue
作者单位	Univ Chinese Acad Sci, Chinese Acad Sci, Inst Nutr Sci, Shanghai Inst Biol Sci,Key Lab Nutr & Metab, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Luo, Wenwen,Ma, Shumin,Yang, Yunzhi,et al. Tfeb regulates per3 expression via glucose-dependent effects on clock/bmal1[J]. International journal of biochemistry & cell biology,2016,78:31-42.
APA	Luo, Wenwen.,Ma, Shumin.,Yang, Yunzhi.,Wang, Chenyao.,Zhang, Deyi.,...&Liu, Zhixue.(2016).Tfeb regulates per3 expression via glucose-dependent effects on clock/bmal1.International journal of biochemistry & cell biology,78,31-42.
MLA	Luo, Wenwen,et al."Tfeb regulates per3 expression via glucose-dependent effects on clock/bmal1".International journal of biochemistry & cell biology 78(2016):31-42.

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