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	Ultra-weak photon emission of hands in aging prediction
	Zhao, Xin1,2; van Wijk, Eduard3,4; Yan, Yu3; van Wijk, Roeland3,4; Yang, Huanming2,5; Zhang, Yan2; Wang, Jian1,2,5
刊名	Journal of photochemistry and photobiology b-biology
	2016-09-01
卷号	162页码:529-534
关键词	Ultra-weak photon emission Model prediction Aging
ISSN号	1011-1344
DOI	10.1016/j.jphotobio1.2016.07.030
通讯作者	Zhang, yan(yanzhang@genomics.cn) ; Wang, jian(jianwang@genomics.cn)
英文摘要	Aging has been one of the several topics intensely investigated during recent decades. more scientists have been scrutinizing mechanisms behind the human aging process. ultra-weak photon emission is known as one type of spontaneous photon emission that can be detected with a highly sensitive single photon counting photomultiplier tube (pmt) from the surface of human bodies. it may reflect the body's oxidative damage. our aim was to examine whether ultra-weak photon emission from a human hand is able to predict one's chronological age. sixty subjects were recruited and grouped by age. we examined four areas of each hand: palm side of fingers, palm side of hand, dorsum side of fingers, and dorsum side of hand. left and right hand were measured synchronously with two independent pmts. mean strength and fano factor values of photon counts were utilized to compare the upe patterns of males and females of different age groups. subsequently, we utilized upe data from the most sensitive pmt to develop an age prediction model. we randomly picked 49 subjects to construct the model, whereas the remaining 11 subjects were utilized for validation. the results demonstrated that the model was a good regression compared to the observed values (pearson's r = 0.6, adjusted r square = 0.4, p = 9.4e - 7, accuracy = 49/60). further analysis revealed that the average difference between the chronological age and predicted age was only 7.6 +/- 0.8 years. it was concluded that this fast and non-invasive photon technology is sufficiently promising to be developed for the estimation of biological aging. (c) 2016 elsevier b.v. all rights reserved.
WOS关键词	HUMAN-BODY ; HUMAN SKIN ; MITOCHONDRIA ; STRESS ; MODEL ; AGE
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	ELSEVIER SCIENCE SA
WOS记录号	WOS:000383003800060
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376217
专题	中国科学院大学
通讯作者	Zhang, Yan; Wang, Jian
作者单位	1.Univ Chinese Acad Sci, BGI Educ Ctr, Shenzhen 518083, Peoples R China 2.BGI Shenzhen, Shenzhen 518083, Peoples R China 3.Meluna Res, Geldermalsen, Netherlands 4.Leiden Univ, Ctr Photon Living Syst, Sinodutch Ctr Prevent & Personalized Med, Leiden, Netherlands 5.James D Watson Inst Genome Sci, Hangzhou 310058, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Xin,van Wijk, Eduard,Yan, Yu,et al. Ultra-weak photon emission of hands in aging prediction[J]. Journal of photochemistry and photobiology b-biology,2016,162:529-534.
APA	Zhao, Xin.,van Wijk, Eduard.,Yan, Yu.,van Wijk, Roeland.,Yang, Huanming.,...&Wang, Jian.(2016).Ultra-weak photon emission of hands in aging prediction.Journal of photochemistry and photobiology b-biology,162,529-534.
MLA	Zhao, Xin,et al."Ultra-weak photon emission of hands in aging prediction".Journal of photochemistry and photobiology b-biology 162(2016):529-534.

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