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	Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity
	He, Wenni1; Liu, Miaomiao1; Li, Xiaolin2; Zhang, Xiaoping3; Abdel-Mageed, Wael M.4,5; Li, Li6,7; Wang, Wenzhao8; Zhang, Jingyu1; Han, Jianying1,12; Dai, Huanqin1
刊名	Applied microbiology and biotechnology
	2016-10-01
卷号	100期号:19页码:8349-8357
关键词	Biotransformation [4+2] cycloaddition reaction Tanshinone iia Hypocrea sp
ISSN号	0175-7598
DOI	10.1007/s00253-016-7488-6
通讯作者	Zhang, lixin(zhanglixin@im.ac.cn) ; Liu, xueting(liuxt2010@gmail.com)
英文摘要	The biotransformation of tanshinone iia to a new antibacterial agent tanshisorbicin (1) by the fungus hypocrea sp. (as 3.17108) is described. the structure of tanshisorbicin is a hybrid of tanshinone iia (2) and sorbicillinol (3). the latter is a metabolite produced by hypocrea sp. the structure of tanshisorbicin was determined using mass spectrometry, nmr spectroscopy, and ecd calculations. the anti-mrsa activity of 1 was found to be significantly higher than that of the parent substrate tan iia. preliminary experiments indicate that tanshisorbicin is formed via a [4+2] cycloaddition reaction that is likely catalyzed by microbial enzyme.
WOS关键词	DIELS-ALDER REACTION ; NATURAL-PRODUCTS ; VERTICILLIUM-INTERTEXTUM ; BIOSYNTHESIS ; BISORBICILLINOLIDE ; BISORBIBUTENOLIDE ; BIOAVAILABILITY ; IDENTIFICATION ; TRANSFORMATION ; INTERMEDIATE
WOS研究方向	Biotechnology & Applied Microbiology
WOS类目	Biotechnology & Applied Microbiology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000383242500008
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376177
专题	中国科学院大学
通讯作者	Zhang, Lixin; Liu, Xueting
作者单位	1.Chinese Acad Sci, Inst Microbiol, Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China 2.Sichuan Acad Agr Sci, Soil & Fertilizer Res Inst, Chengdu 610066, Peoples R China 3.Sichuan Agr Univ, Dept Microbiol, Coll Resource & Environm, Chengdu 611130, Peoples R China 4.King Saud Univ, Dept Pharmacognosy, Coll Pharm, Riyadh 11451, Saudi Arabia 5.Assiut Univ, Dept Pharmacognosy, Fac Pharm, Assiut 71526, Egypt 6.Chinese Acad Med Sci, Inst Mat Med, Dept Med Chem, Beijing 100050, Peoples R China 7.Peking Union Med Coll, Beijing 100050, Peoples R China 8.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing, Peoples R China 9.Univ Texas Austin, Coll Pharm, Div Med Chem, Austin, TX 78712 USA 10.Univ Texas Austin, Dept Chem, Austin, TX 78712 USA
推荐引用方式 GB/T 7714	He, Wenni,Liu, Miaomiao,Li, Xiaolin,et al. Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity[J]. Applied microbiology and biotechnology,2016,100(19):8349-8357.
APA	He, Wenni.,Liu, Miaomiao.,Li, Xiaolin.,Zhang, Xiaoping.,Abdel-Mageed, Wael M..,...&Liu, Xueting.(2016).Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity.Applied microbiology and biotechnology,100(19),8349-8357.
MLA	He, Wenni,et al."Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity".Applied microbiology and biotechnology 100.19(2016):8349-8357.

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