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	Copper(ii)-graphitic carbon nitride triggered synergy: improved ros generation and reduced glutathione levels for enhanced photodynamic therapy
	Ju, Enguo1,2,3,4,5; Dong, Kai1,3,4; Chen, Zhaowei1,3,4; Liu, Zhen1,3,4; Liu, Chaoqun2,5; Huang, Yanyan2,5; Wang, Zhenzhen2,5; Pu, Fang1,3,4; Ren, Jinsong1,3,4; Qu, Xiaogang1,3,4
刊名	Angewandte chemie-international edition
	2016-09-12
卷号	55期号:38页码:11467-11471
关键词	Glutathione Graphitic carbon nitride Photodynamic therapy Reactive oxygen species Synergetic effects
ISSN号	1433-7851
DOI	10.1002/anie.201605509
通讯作者	Ren, jinsong(jren@ciac.ac.cn) ; Qu, xiaogang(xqu@ciac.ac.cn)
英文摘要	Graphitic carbon nitride (g-c3n4) has been used as photosensitizer to generate reactive oxygen species (ros) for photodynamic therapy (pdt). however, its therapeutic efficiency was far from satisfactory. one of the major obstacles was the overexpression of glutathione (gsh) in cancer cells, which could diminish the amount of generated ros before their arrival at the target site. herein, we report that the integration of cu2+ and g-c3n4 nanosheets (cu2+-g-c3n4) led to enhanced light-triggered ros generation as well as the depletion of intracellular gsh levels. consequently, the ros generated under light irradiation could be consumed less by reduced gsh, and efficiency was improved. importantly, redox-active species cu+-g-c3n4 could catalyze the reduction of molecular oxygen to the superoxide anion or hydrogen peroxide to the hydroxyl radical, both of which facilitated the generation of ros. this synergy of improved ros generation and gsh depletion could enhance the efficiency of pdt for cancer therapy.
WOS关键词	ULTRATHIN 2-DIMENSIONAL NANOMATERIALS ; PHASE C3N4 NANOSHEETS ; ELECTRONIC-STRUCTURE ; CANCER ; ELECTROCATALYSTS ; NANOPARTICLES ; COMBINATION ; ACTIVATION ; LIGHT
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000383748900025
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376070
专题	中国科学院大学
通讯作者	Ren, Jinsong; Qu, Xiaogang
作者单位	1.Changchun Inst Appl Chem, Chinese Acad Sci, Lab Chem Biol & State Key Lab Rare Earth Resource, Changchun 130022, Kagawa, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, Biol Chem Lab, Changchun 130022, Jilin, Peoples R China 4.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Ju, Enguo,Dong, Kai,Chen, Zhaowei,et al. Copper(ii)-graphitic carbon nitride triggered synergy: improved ros generation and reduced glutathione levels for enhanced photodynamic therapy[J]. Angewandte chemie-international edition,2016,55(38):11467-11471.
APA	Ju, Enguo.,Dong, Kai.,Chen, Zhaowei.,Liu, Zhen.,Liu, Chaoqun.,...&Qu, Xiaogang.(2016).Copper(ii)-graphitic carbon nitride triggered synergy: improved ros generation and reduced glutathione levels for enhanced photodynamic therapy.Angewandte chemie-international edition,55(38),11467-11471.
MLA	Ju, Enguo,et al."Copper(ii)-graphitic carbon nitride triggered synergy: improved ros generation and reduced glutathione levels for enhanced photodynamic therapy".Angewandte chemie-international edition 55.38(2016):11467-11471.

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