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	Loss of rig-i leads to a functional replacement with mda5 in the chinese tree shrew
	Xu, Ling1; Yu, Dandan1; Fan, Yu1; Peng, Li1; Wu, Yong1,2; Yao, Yong-Gang1,2,3
刊名	Proceedings of the national academy of sciences of the united states of america
	2016-09-27
卷号	113期号:39页码:10950-10955
关键词	Rig-i Mda5 Tree shrew Positive selection Functional replacement
ISSN号	0027-8424
DOI	10.1073/pnas.1604939113
通讯作者	Yao, yong-gang(yaoyg@mail.kiz.ac.cn)
英文摘要	The function of the rig-i-like receptors (rlrs; including rig-i, mda5, and lgp2) as key cytoplasmic sensors of viral pathogen-associated molecular patterns (pamps) has been subjected to numerous pathogenic challenges and has undergone a dynamic evolution. we found evolutionary evidence that rig-i was lost in the chinese tree shrew lineage. along with the loss of rig-i, both mda5 (tmda5) and lgp2 (tlgp2) have undergone strong positive selection in the tree shrew. tmda5 or tmda5/tlgp2 could sense sendai virus (an rna virus posed as a rig-i agonist) for inducing type i ifn, although conventional rig-i and mda5 were thought to recognize distinct rna structures and viruses. tmda5 interacted with adaptor tmita (stingtmem173/eris), which was reported to bind only with rig-i. the positively selected sites in tmda5 endowed the substitute function for the lost rig-i. these findings provided insights into the adaptation and functional diversity of innate antiviral activity in vertebrates.
WOS关键词	INNATE IMMUNE-SYSTEM ; AMINO-ACID SITES ; RNA HELICASE ; ANTIVIRAL RESPONSES ; SIGNAL-TRANSDUCTION ; POSITIVE SELECTION ; LGP2 ; RECOGNITION ; ACTIVATION ; RECEPTORS
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATL ACAD SCIENCES
WOS记录号	WOS:000383954700053
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375876
专题	中国科学院大学
通讯作者	Yao, Yong-Gang
作者单位	1.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650204, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Kunming Primate Res Ctr, Kunming 650223, Peoples R China
推荐引用方式 GB/T 7714	Xu, Ling,Yu, Dandan,Fan, Yu,et al. Loss of rig-i leads to a functional replacement with mda5 in the chinese tree shrew[J]. Proceedings of the national academy of sciences of the united states of america,2016,113(39):10950-10955.
APA	Xu, Ling,Yu, Dandan,Fan, Yu,Peng, Li,Wu, Yong,&Yao, Yong-Gang.(2016).Loss of rig-i leads to a functional replacement with mda5 in the chinese tree shrew.Proceedings of the national academy of sciences of the united states of america,113(39),10950-10955.
MLA	Xu, Ling,et al."Loss of rig-i leads to a functional replacement with mda5 in the chinese tree shrew".Proceedings of the national academy of sciences of the united states of america 113.39(2016):10950-10955.

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