| Viral specific cytotoxic t cells inhibit the growth of tfr-expressing tumor cells with antibody targeted viral peptide/hla-a2 complex | |
| Li, Jianan1,2; Weng, Xiufang1; Liang, Zhihui1; Zhong, Maohua1,4; Chen, Xueling1,3; Lu, Shengjun1; Sun, Wei1; Song, Yinhong1; Wu, Xiongwen1; Shen, Guanxin1 | |
| 刊名 | Cellular immunology
 |
| 2010 | |
| 卷号 | 263期号:2页码:154-160 |
| 关键词 | Tumor Immunotherapy Viral peptide/hla-a2/tfrscfv Viral peptide-specific ctls |
| ISSN号 | 0008-8749 |
| DOI | 10.1016/j.cellimm.2010.03.008 |
| 通讯作者 | Shen, guanxin() |
| 英文摘要 | A fusion protein of single chain antibody (scfv) specific for transferrin receptor (tfr, cd71) and viral peptide/hla-a2 complex was prepared in this study to redirect cytotoxic t cells (ctls) of viral specificity to tumor cells by attaching the ligand of t cell receptor (tcr) to tumor cells via binding of tfr scfv to tfr. the results demonstrate that the fusion protein can attach the active virus-peptide/hla-a2 complex to hla class i-negative, tfr-expressing k562 cells through binding of tfr scfv to tfr, and mediate cytotoxicity of viral peptide-specific ctls against k562 cells in vitro in addition, the fusion protein can induce inhibition of solid tumor formation and improve survival time in tumor xenograft nude mouse with the injection of the sorted viral peptide-specific ctls generated by co-culture of peripheral blood lymphocytes from hla-a2 positive donors with inactivated t2 cells pulsed with the viral peptide published by elsevier inc |
| WOS关键词 | CLASS I/PEPTIDE COMPLEXES ; EPSTEIN-BARR-VIRUS ; CLASS-I MHC ; TRANSFERRIN RECEPTOR ; ESCHERICHIA-COLI ; EFFECTOR-CELLS ; CANCER-CELLS ; CTL ACTIVITY ; SINGLE ; LYMPHOCYTES |
| WOS研究方向 | Cell Biology ; Immunology |
| WOS类目 | Cell Biology ; Immunology |
| 语种 | 英语 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| WOS记录号 | WOS:000278666800004 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2375759 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Shen, Guanxin |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Dept Immunol, Tongji Med Coll, Wuhan 430030, Peoples R China 2.Jianghan Univ, Dept Biotechnol, Life Sci Coll, Wuhan 430056, Peoples R China 3.Shihezi Univ, Dept Immunol, Sch Med, Shihezi 832002, Peoples R China 4.Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jianan,Weng, Xiufang,Liang, Zhihui,et al. Viral specific cytotoxic t cells inhibit the growth of tfr-expressing tumor cells with antibody targeted viral peptide/hla-a2 complex[J]. Cellular immunology,2010,263(2):154-160. |
| APA | Li, Jianan.,Weng, Xiufang.,Liang, Zhihui.,Zhong, Maohua.,Chen, Xueling.,...&Shen, Guanxin.(2010).Viral specific cytotoxic t cells inhibit the growth of tfr-expressing tumor cells with antibody targeted viral peptide/hla-a2 complex.Cellular immunology,263(2),154-160. |
| MLA | Li, Jianan,et al."Viral specific cytotoxic t cells inhibit the growth of tfr-expressing tumor cells with antibody targeted viral peptide/hla-a2 complex".Cellular immunology 263.2(2010):154-160. |
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