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	M2bp inhibits hiv-1 virion production in a vimentin filaments-dependent manner
	Wang, Qin1,2; Zhang, Xiaolin1,2; Han, Yuling1,2; Wang, Xinlu1; Gao, Guangxia1
刊名	Scientific reports
	2016-09-08
卷号	6页码:14
ISSN号	2045-2322
DOI	10.1038/srep32736
通讯作者	Wang, xinlu(wang_xl1978@aliyun.com) ; Gao, guangxia(gaogx@moon.ibp.ac.cn)
英文摘要	M2bp (also called 90k) is an interferon-stimulated gene product that is upregulated in hiv-1 infection. a recent study revealed that m2bp reduces the infectivity of hiv-1 by inhibiting the processing of the viral envelope protein. here we report that in addition to reducing viral infectivity, m2bp inhibits hiv-1 virion production. we provide evidence showing that m2bp inhibits hiv-1 gag trafficking to the plasma membrane in a vimentin-dependent manner. when vimentin filaments were collapsed by treating cells with acrylamide or by overexpression of a dominant-negative mutant of vimentin, m2bp inhibition of hiv-1 virion production was significantly relieved. we further show that m2bp interacts with both hiv-1 gag and vimentin and thereby mediates their interactions. we propose that m2bp traps hiv-1 gag to vimentin filaments to inhibit the transportation of hiv-1 gag to the plasma membrane. these findings uncover a novel mechanism by which a host antiviral factor inhibits hiv-1 virion production.
WOS关键词	IMMUNODEFICIENCY-VIRUS TYPE-1 ; TUMOR-ASSOCIATED ANTIGEN ; INTERMEDIATE-FILAMENTS ; MAC-2-BINDING PROTEIN ; CENTRIOLE BIOGENESIS ; BINDING-PROTEIN ; CARCINOMA CELLS ; CAPSID PROTEIN ; 90K ANTIGEN ; INFECTION
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000382640300001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375680
专题	中国科学院大学
通讯作者	Wang, Xinlu; Gao, Guangxia
作者单位	1.Chinese Acad Sci, Inst Biophys, Key Lab Infect & Immun, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Qin,Zhang, Xiaolin,Han, Yuling,et al. M2bp inhibits hiv-1 virion production in a vimentin filaments-dependent manner[J]. Scientific reports,2016,6:14.
APA	Wang, Qin,Zhang, Xiaolin,Han, Yuling,Wang, Xinlu,&Gao, Guangxia.(2016).M2bp inhibits hiv-1 virion production in a vimentin filaments-dependent manner.Scientific reports,6,14.
MLA	Wang, Qin,et al."M2bp inhibits hiv-1 virion production in a vimentin filaments-dependent manner".Scientific reports 6(2016):14.

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