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	Mglur1 and mglur5 synergistically control cholinergic synaptic transmission in the thalamic reticular nucleus
	Sun, Yan-Gang1,2; Rupprecht, Vanessa1,5; Zhou, Li2,3; Dasgupta, Rajan1,4; Seibt, Frederik1; Beierlein, Michael1,4
刊名	Journal of neuroscience
	2016-07-27
卷号	36期号:30页码:7886-7896
关键词	Acetylcholine Basal forebrain Long-term plasticity Metabotropic glutamate receptor Synergistic Thalamic reticular nucleus
ISSN号	0270-6474
DOI	10.1523/jneurosci.0409-16.2016
通讯作者	Beierlein, michael(michael.beierlein@uth.tmc.edu)
英文摘要	Acetylcholine (ach) signaling is involved in a wide range of processes, including arousal, attention, and learning. an increasing number of studies indicate that cholinergic control of these functions is highly deterministic, mediated by synaptic afferents that generate reliable and precise responses in postsynaptic neurons. however, mechanisms that govern plastic changes of cholinergic synaptic strength are poorly understood, even though they are likely critical in shaping the impact of cholinergic inputs on neuronal networks. we have recently shown that in the thalamic reticular nucleus (trn), synaptic release of ach generates excitatory-inhibitory biphasic postsynaptic responses, mediated by the activation of alpha 4 beta 2 nicotinic (nachrs) and m2 muscarinic receptors (machrs), respectively. here, using voltage-clamp recordings from trn neurons in thalamocortical slices of mice, we demonstrate that the activation of group i metabotropic glutamate receptors (mglurs) by ambient or synaptically released glutamate evokes transient increases of nicotinic epscs. additionally, we find that the selective group i mglur agonist dhpg [(s)-3,5-dihydroxyphenylglycine] evokes long-term potentiation of nicotinic epscs (mglur-nltp), dependent on increases in postsynaptic ca2+ concentration and the activation of phospholipase c. both the induction and the maintenance of mglur-nltp require synergistic activation of mglur1 and mglur5. together, our results show that postsynaptic group i mglurs are critically involved in the regulation of cholinergic synaptic strength on different time scales, suggesting that cholinergic control of local thalamic circuits is highly context-dependent and regulated by the overall levels of glutamatergic afferent activity.
WOS关键词	METABOTROPIC GLUTAMATE RECEPTORS ; LONG-TERM DEPRESSION ; BASAL FOREBRAIN NEURONS ; GROUP-I ; DISCHARGE PROFILES ; BARREL CORTEX ; CA1 REGION ; INHIBITION ; ACTIVATION ; RAT
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
语种	英语
出版者	SOC NEUROSCIENCE
WOS记录号	WOS:000382300200010
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375673
专题	中国科学院大学
通讯作者	Beierlein, Michael
作者单位	1.McGovern Med Sch, Dept Neurobiol & Anat, 6431 Fannin,Suite 7-046, Houston, TX 77030 USA 2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Neurosci,State Key Lab Neurosci, Shanghai 200031, Peoples R China 3.Univ Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China 4.Univ Texas Houston, Grad Sch Biomed Sci Houston, Houston, TX 77030 USA 5.Univ Regensburg, Inst Zool, Neurophysiol, Univ Str 31, D-93040 Regensburg, Germany
推荐引用方式 GB/T 7714	Sun, Yan-Gang,Rupprecht, Vanessa,Zhou, Li,et al. Mglur1 and mglur5 synergistically control cholinergic synaptic transmission in the thalamic reticular nucleus[J]. Journal of neuroscience,2016,36(30):7886-7896.
APA	Sun, Yan-Gang,Rupprecht, Vanessa,Zhou, Li,Dasgupta, Rajan,Seibt, Frederik,&Beierlein, Michael.(2016).Mglur1 and mglur5 synergistically control cholinergic synaptic transmission in the thalamic reticular nucleus.Journal of neuroscience,36(30),7886-7896.
MLA	Sun, Yan-Gang,et al."Mglur1 and mglur5 synergistically control cholinergic synaptic transmission in the thalamic reticular nucleus".Journal of neuroscience 36.30(2016):7886-7896.

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