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	Chloropestolide a, an antitumor metabolite with an unprecedented spiroketal skeleton from pestalotiopsis fici
	Liu, Ling1; Li, Yan1; Liu, Shuchun1; Zheng, Zhihui2; Chen, Xulin3; Zhang, Hua2; Guo, Liangdong1; Che, Yongsheng1
刊名	Organic letters
	2009-07-02
卷号	11期号:13页码:2836-2839
ISSN号	1523-7060
DOI	10.1021/ol901039m
通讯作者	Che, yongsheng(cheys@im.ac.cn)
英文摘要	Chloropestolide a (1), a highly functionalized spiroketal with an unprecedented skeleton derived from a chlorinated bicyclo-[2.2.2]-oct-2-en-5-one ring and a 2,6-dihydroxy-4-methylbenzoic acid unit, has been isolated from the scale-up fermentation extract of pestalotiopsis fici. the structure of 1 was elucidated by nmr spectroscopy and x-ray crystallography. 1 could be derived from the same diels-aider precursors as 2 and showed significant inhibitory effects on growth of two human cancer cell lines, hela and ht29, with gi(50) values of 0.7 and 4.2 mu m, respectively.
WOS关键词	OBTUSA VAR.-FORMOSANA ; ENDOPHYTIC FUNGUS ; A-D ; DERIVATIVES ; MICROSPORA ; ANTIFUNGAL ; CHEMISTRY ; HEARTWOOD ; THEAE ; ACID
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000267400100031
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375574
专题	武汉病毒研究所
通讯作者	Che, Yongsheng
作者单位	1.Chinese Acad Sci, Inst Microbiol, Key Lab Systemat Mycol & Lichenol, Beijing 100190, Peoples R China 2.N China Pharmaceut Grp Corp, New Drug Res & Dev Ctr, Shijiazhuang 050015, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Liu, Ling,Li, Yan,Liu, Shuchun,et al. Chloropestolide a, an antitumor metabolite with an unprecedented spiroketal skeleton from pestalotiopsis fici[J]. Organic letters,2009,11(13):2836-2839.
APA	Liu, Ling.,Li, Yan.,Liu, Shuchun.,Zheng, Zhihui.,Chen, Xulin.,...&Che, Yongsheng.(2009).Chloropestolide a, an antitumor metabolite with an unprecedented spiroketal skeleton from pestalotiopsis fici.Organic letters,11(13),2836-2839.
MLA	Liu, Ling,et al."Chloropestolide a, an antitumor metabolite with an unprecedented spiroketal skeleton from pestalotiopsis fici".Organic letters 11.13(2009):2836-2839.

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