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	Facile fabrication of double-walled polymeric hollow spheres with independent temperature and ph dual-responsiveness for synergetic drug delivery
	Cheng, Nan1; Wang, Yu1,2; Wu, Feipeng1
刊名	Journal of applied polymer science
	2016-12-01
卷号	133期号:48页码:10
关键词	Biomedical applications Drug delivery systems Phase behavior Swelling
ISSN号	0021-8995
DOI	10.1002/app.44335
通讯作者	Wu, feipeng(fpwu@mail.ipc.ac.cn)
英文摘要	A dual-responsive double-walled polymeric hollow sphere (phs) serving as a candidate for synergetic drug delivery platform is prepared by a simple and green template polymerization in aqueous medium. the phs, comprised of thermo-responsive crosslinked poly(n-isopropylacrylamide) (pnipam) as the inner shell and ph-responsive crosslinked poly(methacrylic acid) (pmaac) as the outer shell, is assembled through self-removal of the thermo-responsive template from a core-triple shell structure by free radical polymerization with sequential addition of reactants. the discrete double-shell structure renders the phs independent temperature and ph-controlled swelling/shrinking capability. taking the advantage of two compartmentalized internal spaces (the core and the interlayer spaces) with independent temperature-and ph-dependent behaviors, two model drugs representing the small molecule and the macromolecule are loaded in selective locations of the phs. two drugs show dramatically different release profiles according to environmental temperature and ph, due to the localization of drugs and the stimuli-dependent property of its protective shells. (c) 2016 wiley periodicals, inc.
WOS关键词	TARGETED CO-DELIVERY ; SHELL THICKNESS ; MICROSPHERES ; RELEASE ; POLYELECTROLYTE ; DOXORUBICIN ; PROTEIN ; NANOPARTICLES ; NANOCAPSULES ; MICROPARTICLES
WOS研究方向	Polymer Science
WOS类目	Polymer Science
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000384673600020
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375049
专题	中国科学院大学
通讯作者	Wu, Feipeng
作者单位	1.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Cheng, Nan,Wang, Yu,Wu, Feipeng. Facile fabrication of double-walled polymeric hollow spheres with independent temperature and ph dual-responsiveness for synergetic drug delivery[J]. Journal of applied polymer science,2016,133(48):10.
APA	Cheng, Nan,Wang, Yu,&Wu, Feipeng.(2016).Facile fabrication of double-walled polymeric hollow spheres with independent temperature and ph dual-responsiveness for synergetic drug delivery.Journal of applied polymer science,133(48),10.
MLA	Cheng, Nan,et al."Facile fabrication of double-walled polymeric hollow spheres with independent temperature and ph dual-responsiveness for synergetic drug delivery".Journal of applied polymer science 133.48(2016):10.

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