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	Electrophoretic-deposited novel ternary silk fibroin/graphene oxide/hydroxyapatite nanocomposite coatings on titanium substrate for orthopedic applications
	Li, Ming1,3; Xiong, Pan3; Mo, Maosong1,2; Cheng, Yan3; Zheng, Yufeng3,4
刊名	Frontiers of materials science
	2016-09-01
卷号	10期号:3页码:270-280
关键词	Graphene oxide Silk fibroin Hydroxyapatite Nano-biocomposite coatings Electrodeposition
ISSN号	2095-025X
DOI	10.1007/s11706-016-0347-7
通讯作者	Mo, maosong(msmo@mail.iee.ac.cn) ; Cheng, yan(chengyan@pku.edu.cn)
英文摘要	The combination of graphene oxide (go) with robust mechanical property, silk fibroin (sf) with fascinating biological effects and hydroxyapatite (ha) with superior osteogenic activity is a competitive approach to make novel coatings for orthopedic applications. herein, the feasibility of depositing ternary sf/go/ha nanocomposite coatings on ti substrate was firstly verified by exploiting electrophoretic nanotechnology, with sf being used as both a charging additive and a dispersion agent. the surface morphology, microstructure and composition, in vitro hemocompatibility and in vitro cytocompatibility of the resulting coatings were investigated by sem, raman, ftir spectra and biocompatibility tests. results demonstrated that go, ha and sf could be co-deposited with a uniform, smooth thin-film morphology. the hemolysis rate analysis and the platelet adhesion test indicated good blood compatibility of the coatings. the human osteosarcoma mg63 cells displayed well adhesion and proliferation behaviors on the prepared coatings, with enhanced alp activities. the present study suggested that sf/go/ha nanocomposite coatings could be a promising candidate for the surface functionalization of biomaterials, especially as orthopedic implant coating.
WOS关键词	MESENCHYMAL STEM-CELLS ; GRAPHENE OXIDE ; CARDIOMYOGENIC DIFFERENTIATION ; OSTEOGENIC DIFFERENTIATION ; PROTEIN SCAFFOLDS ; DENTAL IMPLANTS ; FIBROIN ; HYDROXYAPATITE ; COMPOSITE ; DELIVERY
WOS研究方向	Materials Science
WOS类目	Materials Science, Multidisciplinary
语种	英语
出版者	HIGHER EDUCATION PRESS
WOS记录号	WOS:000381204000004
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375005
专题	中国科学院大学
通讯作者	Mo, Maosong; Cheng, Yan
作者单位	1.Chinese Acad Sci, Inst Elect Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Elect Elect & Commun Engn, Beijing 100049, Peoples R China 3.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China 4.Peking Univ, Dept Mat Sci & Engn, Coll Engn, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Li, Ming,Xiong, Pan,Mo, Maosong,et al. Electrophoretic-deposited novel ternary silk fibroin/graphene oxide/hydroxyapatite nanocomposite coatings on titanium substrate for orthopedic applications[J]. Frontiers of materials science,2016,10(3):270-280.
APA	Li, Ming,Xiong, Pan,Mo, Maosong,Cheng, Yan,&Zheng, Yufeng.(2016).Electrophoretic-deposited novel ternary silk fibroin/graphene oxide/hydroxyapatite nanocomposite coatings on titanium substrate for orthopedic applications.Frontiers of materials science,10(3),270-280.
MLA	Li, Ming,et al."Electrophoretic-deposited novel ternary silk fibroin/graphene oxide/hydroxyapatite nanocomposite coatings on titanium substrate for orthopedic applications".Frontiers of materials science 10.3(2016):270-280.

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