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	Inhibitory mechanism of butylated hydroxyanisole against infection of fusarium proliferatum based on comparative proteomic analysis
	Li, Taotao1,5; Jian, Quie1,5; Wang, Yong2; Chen, Feng3; Yang, Chengwei4; Gong, Liang1; Duan, Xuewu1; Yang, Bao1; Jiang, Yueming1
刊名	Journal of proteomics
	2016-10-04
卷号	148页码:1-11
关键词	Fusarium proliferatum Butylated hydroxyanisole Proteomic Secretome Pathogenic ability Antifungal agent
ISSN号	1874-3919
DOI	10.1016/j.jprot.2016.04.051
通讯作者	Jiang, yueming(ymjiang@scbg.ac.cn)
英文摘要	Fusarium proliferatum as a filamentous fungal pathogen can produce mycotoxins that can contaminate postharvest fruits and thus impact risks on human health. the extracellular proteomes of f. proliferatum grown in the absence and presence of butylated hydroxyanisole (bha) were analyzed comparatively. a total of 66 significantly different expressed secreted proteins were identified by lc-esi-ms/ms analysis. the bha treatment suppressed the accumulation of some pathogenic factors such as aspartic protease, cell wall degradation enzymes, porin, superoxide dismutase and glyceraldehyde-3-phosphate dehydrogenase. on the contrary, the bha treatment increased the abundances of some proteins, such as atp binding cassette transporter substrate-binding protein and lipopolysaccharide-assembly lipoprotein, involved in the growth of f. proliferatum. these findings suggest that bha treatment could influence the pathogenic ability of f. proliferatum via inhibiting the levels of virulence factors and cell wall degradation-associated enzymes. moreover, the induction of the growth-related proteins after the bha treatment suggests that the livelihood of f. proliferatum might depend on the cost of reduced pathogenic ability. this study has provided some evidence for understanding the complicated mechanisms of f. proliferatum infection in an effort to develop new targets for the control of this fungal pathogen. biological significance: to better understand the inhibitory mechanism of f. proliferatum by butylated hydroxyanisole (bha) treatment, a comprehensive proteomic analysis of the secreted proteins of f. proliferatum was firstly conducted. among the 66 identified spots, 34 and 32 proteins were down- and up-accumulated significantly by bha treatment, respectively. many of the identified key protein species were involved in the pathogenic ability and the growth of f. proliferatum. this study is helpful for broadening our knowledge of the pathogenic mechanism of f. proliferatum. (c) 2016 elsevier b.v. all rights reserved.
WOS关键词	SUBSTRATE-BINDING PROTEINS ; BOTRYTIS-CINEREA SECRETOME ; PSEUDOMONAS-AERUGINOSA ; FUMONISIN PRODUCTION ; CANDIDA-ALBICANS ; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE ; ESCHERICHIA-COLI ; GENE-EXPRESSION ; OUTER-MEMBRANE ; MAIZE GRAIN
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemical Research Methods
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000385599700001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374816
专题	中国科学院大学
通讯作者	Jiang, Yueming
作者单位	1.Chinese Acad Sci, Key Lab Plant Resource Conservat & Sustainable Ut, Guangdong Prov Key Lab Appl Bot, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China 2.Zhong Shan Entry Exit Inspect & Quarantine Bur, Zhongshan 528403, Peoples R China 3.Clemson Univ, Dept Food Nutr & Packaging Sci, Clemson, SC 29634 USA 4.South China Normal Univ, Coll Life Sci, Guangdong Prov Key Lab Biotechnol Plant Dev, Guangzhou 510631, Guangdong, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Li, Taotao,Jian, Quie,Wang, Yong,et al. Inhibitory mechanism of butylated hydroxyanisole against infection of fusarium proliferatum based on comparative proteomic analysis[J]. Journal of proteomics,2016,148:1-11.
APA	Li, Taotao.,Jian, Quie.,Wang, Yong.,Chen, Feng.,Yang, Chengwei.,...&Jiang, Yueming.(2016).Inhibitory mechanism of butylated hydroxyanisole against infection of fusarium proliferatum based on comparative proteomic analysis.Journal of proteomics,148,1-11.
MLA	Li, Taotao,et al."Inhibitory mechanism of butylated hydroxyanisole against infection of fusarium proliferatum based on comparative proteomic analysis".Journal of proteomics 148(2016):1-11.

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