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	Mechanistic insights into the distribution of carbohydrate clusters on cell membranes revealed by dstorm imaging
	Chen, Junling1,2; Gao, Jing1; Cai, Mingjun1; Xu, Haijiao1; Jiang, Junguang1; Tian, Zhiyuan3; Wang, Hongda1
刊名	Nanoscale
	2016
卷号	8期号:28页码:13611-13619
ISSN号	2040-3364
DOI	10.1039/c6nr02513g
通讯作者	Wang, hongda(hdwang@ciac.ac.cn)
英文摘要	Cell surface carbohydrates play significant roles in many physiological processes and act as primary markers to indicate various cellular physiological states. the functions of carbohydrates are always associated with their expression and distribution on cell membranes. based on our previous work, we found that carbohydrates tend to form clusters; however, the underlying mechanism of these clusters remains unknown. through the direct stochastic optical reconstruction microscopy (dstorm) strategy, we found that with the contributions of lipid raft as a stable factor and actin cytoskeleton as a restrictive factor, carbohydrate clusters can stably exist with restricted size. additionally, we revealed that the formation of most carbohydrate clusters (gal and glcanc clusters) depended on the carbohydrate-binding proteins (i.e., galectins) cross-linking their specific carbohydrate ligands. our results clarify the organizational mechanism of carbohydrates on cell surfaces from their formation, stable existence and size-restriction, which promotes a better understanding of the relationship between the function and distribution of carbohydrates, as well as the structure of cell membranes.
WOS关键词	ATOMIC-FORCE MICROSCOPY ; PLASMA-MEMBRANE ; LIPID RAFTS ; N-GLYCANS ; PROTEIN ; SURFACE ; ORGANIZATION ; LATTICES ; CANCER ; MODEL
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000380021100012
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374553
专题	中国科学院大学
通讯作者	Wang, Hongda
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Chen, Junling,Gao, Jing,Cai, Mingjun,et al. Mechanistic insights into the distribution of carbohydrate clusters on cell membranes revealed by dstorm imaging[J]. Nanoscale,2016,8(28):13611-13619.
APA	Chen, Junling.,Gao, Jing.,Cai, Mingjun.,Xu, Haijiao.,Jiang, Junguang.,...&Wang, Hongda.(2016).Mechanistic insights into the distribution of carbohydrate clusters on cell membranes revealed by dstorm imaging.Nanoscale,8(28),13611-13619.
MLA	Chen, Junling,et al."Mechanistic insights into the distribution of carbohydrate clusters on cell membranes revealed by dstorm imaging".Nanoscale 8.28(2016):13611-13619.

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