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	Microbial production of vitamin b12: a review and future perspectives
	Fang,Huan1,2,3; Kang,Jie1,4; Zhang,Dawei1,2
刊名	Microbial cell factories
	2017-01-30
卷号	16期号:1
关键词	Vitamin b12 Biosynthesis Metabolic regulation Synthetic biology Escherichia coli Metabolic engineering
ISSN号	1475-2859
DOI	10.1186/s12934-017-0631-y
通讯作者	Zhang,dawei(zhang_dw@tib.cas.cn)
英文摘要	Abstractvitamin b12 is an essential vitamin that is widely used in medical and food industries. vitamin b12 biosynthesis is confined to few bacteria and archaea, and as such its production relies on microbial fermentation. rational strain engineering is dependent on efficient genetic tools and a detailed knowledge of metabolic pathways, regulation of which can be applied to improve product yield. recent advances in synthetic biology and metabolic engineering have been used to efficiently construct many microbial chemical factories. many published reviews have probed the vitamin b12 biosynthetic pathway. to maximize the potential of microbes for vitamin b12 production, new strategies and tools are required. in this review, we provide a comprehensive understanding of advances in the microbial production of vitamin b12, with a particular focus on establishing a heterologous host for the vitamin b12 production, as well as on strategies and tools that have been applied to increase microbial cobalamin production. several worthy strategies employed for other products are also included.
语种	英语
出版者	BioMed Central
WOS记录号	BMC:10.1186/S12934-017-0631-Y
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374342
专题	中国科学院大学
通讯作者	Zhang,Dawei
作者单位	1.Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology 2.Chinese Academy of Sciences; Key Laboratory of Systems Microbial Biotechnology 3.University of Chinese Academy of Sciences 4.Tianjin University of Commerce; College of Biotechnology and Food Science
推荐引用方式 GB/T 7714	Fang,Huan,Kang,Jie,Zhang,Dawei. Microbial production of vitamin b12: a review and future perspectives[J]. Microbial cell factories,2017,16(1).
APA	Fang,Huan,Kang,Jie,&Zhang,Dawei.(2017).Microbial production of vitamin b12: a review and future perspectives.Microbial cell factories,16(1).
MLA	Fang,Huan,et al."Microbial production of vitamin b12: a review and future perspectives".Microbial cell factories 16.1(2017).

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