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	Influenza h7n9 lah-hbc virus-like particle vaccine with adjuvant protects mice against homologous and heterologous influenza viruses
	Zheng, Dan1; Chen, Shaoheng1; Qu, Di2; Chen, Jianjun3; Wang, Fuyan4; Zhang, Ran5; Chen, Ze1,5
刊名	Vaccine
	2016-12-12
卷号	34期号:51页码:6464-6471
关键词	Influenza H7n9 Lah-hbc vlp Adjuvant
ISSN号	0264-410X
DOI	10.1016/j.vaccine.2016.11.026
通讯作者	Chen, ze(chenze2005@hotmail.com)
英文摘要	The long alpha-helix (lah) region located in influenza virus hemagglutinin (ha) shows conservation among different influenza a strains, which could be used as a candidate target of influenza vaccines. moreover, the hepatitis b virus core protein (hbc) is a carrier for heterologous epitopes in eliciting effective immune responses. we inserted the lah region of h7n9 influenza virus into the hbc and prepared the lah-hbc protein, which were capable of self-assembly into virus-like particles (vlp), by using e. coli expression system. intranasal immunization of the lah-hbc vlp in combination with chitosan adjuvant or ctb* adjuvant in mice could induce both humoral and cellular immune responses effectively and provide complete protection against lethal challenge of homologous h7n9 virus or heterologous h3n2 virus, as well as partial protection against lethal challenge of heterologous h1n1 virus. these results provide a proof of concept for lah-hbc vlp vaccine that would be fast and easy to be produced and might be an ideal candidate as a rapid-response tool against a future influenza pandemic. (c) 2016 elsevier ltd. all rights reserved.
WOS关键词	TOXIN-B SUBUNIT ; IMMUNOGLOBULIN-A ; INTRACELLULAR NEUTRALIZATION ; CROSS-PROTECTION ; ANTIBODIES ; INDUCTION ; INFECTION ; CHALLENGE ; EPITOPES ; IMMUNITY
WOS研究方向	Immunology ; Research & Experimental Medicine
WOS类目	Immunology ; Medicine, Research & Experimental
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000390506100003
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373485
专题	武汉病毒研究所
通讯作者	Chen, Ze
作者单位	1.Shanghai Inst Biol Prod, Shanghai 200052, Peoples R China 2.Fudan Univ, Biosafety Level Lab 3, Shanghai 200032, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 4.Cent S Univ, Xiangya Sch Med, Dept Immunol, Changsha 410078, Hunan, Peoples R China 5.Hunan Normal Univ, Coll Med, Changsha 410013, Hunan, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Dan,Chen, Shaoheng,Qu, Di,et al. Influenza h7n9 lah-hbc virus-like particle vaccine with adjuvant protects mice against homologous and heterologous influenza viruses[J]. Vaccine,2016,34(51):6464-6471.
APA	Zheng, Dan.,Chen, Shaoheng.,Qu, Di.,Chen, Jianjun.,Wang, Fuyan.,...&Chen, Ze.(2016).Influenza h7n9 lah-hbc virus-like particle vaccine with adjuvant protects mice against homologous and heterologous influenza viruses.Vaccine,34(51),6464-6471.
MLA	Zheng, Dan,et al."Influenza h7n9 lah-hbc virus-like particle vaccine with adjuvant protects mice against homologous and heterologous influenza viruses".Vaccine 34.51(2016):6464-6471.

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