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	Autographa californica multiple nucleopolyhedrovirus ac34 protein retains cellular actin-related protein 2/3 complex in the nucleus by subversion of crm1-dependent nuclear export
	Mu, Jingfang1,2,5; Zhang, Yongli1,2; Hu, Yangyang1,2; Hu, Xue1; Zhou, Yuan1; Zhao, He1; Pei, Rongjuan1; Wu, Chunchen1; Chen, Jizheng1; Zhao, Han1,2
刊名	Plos pathogens
	2016-11-01
卷号	12期号:11页码:22
ISSN号	1553-7366
DOI	10.1371/journal.ppat.1005994
通讯作者	Chen, xinwen(chenxw@wh.iov.cn) ; Wang, yun(wangyun@wh.iov.cn)
英文摘要	Actin, nucleation-promoting factors (npfs), and the actin-related protein 2/3 complex (arp2/3) are key elements of the cellular actin polymerization machinery. with nuclear actin polymerization implicated in ever-expanding biological processes and the discovery of the nuclear import mechanisms of actin and npfs, determining arp2/3 nucleo-cytoplasmic shuttling mechanism is important for understanding the function of nuclear actin. a unique feature of alphabaculovirus infection of insect cells is the robust nuclear accumulation of arp2/3, which induces actin polymerization in the nucleus to assist in virus replication. we found that ac34, a viral late gene product encoded by the alphabaculovirus autographa californica multiple nucleopolyhedrovirus (acmnpv), is involved in arp2/3 nuclear accumulation during virus infection. further assays revealed that the subcellular distribution of arp2/3 under steady-state conditions is controlled by chromosomal maintenance 1 (crm1)-dependent nuclear export. upon acmnpv infection, ac34 inhibits crm1 pathway and leads to arp2/3 retention in the nucleus.
WOS关键词	HELICOVERPA-ARMIGERA NUCLEOPOLYHEDROVIRUS ; MAJOR CAPSID PROTEIN ; ARP2/3 COMPLEX ; PORE COMPLEX ; NUCLEOCYTOPLASMIC TRANSPORT ; NUCLEOCAPSID PROTEIN ; POLYHEDROSIS-VIRUS ; IMPORT RECEPTORS ; F-ACTIN ; MOTILITY
WOS研究方向	Microbiology ; Parasitology ; Virology
WOS类目	Microbiology ; Parasitology ; Virology
语种	英语
出版者	PUBLIC LIBRARY SCIENCE
WOS记录号	WOS:000392193200027
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373479
专题	武汉病毒研究所
通讯作者	Chen, Xinwen; Wang, Yun
作者单位	1.Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Sun Yat Sen Univ, State Key Lab Biocontrol, Guangzhou, Guangdong, Peoples R China 4.Wageningen Univ, Virol Lab, Wageningen, Netherlands 5.Wuhan Univ, Sch Basic Med Sci, Wuhan, Peoples R China
推荐引用方式 GB/T 7714	Mu, Jingfang,Zhang, Yongli,Hu, Yangyang,et al. Autographa californica multiple nucleopolyhedrovirus ac34 protein retains cellular actin-related protein 2/3 complex in the nucleus by subversion of crm1-dependent nuclear export[J]. Plos pathogens,2016,12(11):22.
APA	Mu, Jingfang.,Zhang, Yongli.,Hu, Yangyang.,Hu, Xue.,Zhou, Yuan.,...&Wang, Yun.(2016).Autographa californica multiple nucleopolyhedrovirus ac34 protein retains cellular actin-related protein 2/3 complex in the nucleus by subversion of crm1-dependent nuclear export.Plos pathogens,12(11),22.
MLA	Mu, Jingfang,et al."Autographa californica multiple nucleopolyhedrovirus ac34 protein retains cellular actin-related protein 2/3 complex in the nucleus by subversion of crm1-dependent nuclear export".Plos pathogens 12.11(2016):22.

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