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	Gpatch3 negatively regulates rlr-mediated innate antiviral responses by disrupting the assembly of visa signalosome
	Nie, Ying1,2; Ran, Yong1; Zhang, Hong-Yan1,2; Huang, Zhe-Fu1,2; Pan, Zhao-Yi1,2; Wang, Su-Yun1; Wang, Yan-Yi1
刊名	Plos pathogens
	2017-04-01
卷号	13期号:4页码:18
ISSN号	1553-7366
DOI	10.1371/journal.ppat.1006328
通讯作者	Wang, yan-yi(wangyy@wh.iov.cn)
英文摘要	Upon viral infection, retinoic acid-inducible gene i-like receptors (rlrs) recognize viral rna and trigger a series of signaling events, leading to the induction of type i interferons (ifns). these processes are delicately regulated to prevent excessive and harmful immune responses. in this study, we identified g patch domain-containing protein 3 (gpatch3) as a negative regulator of rlr-mediated antiviral signaling pathways. overexpression of gpatch3 impaired rna virus-triggered induction of downstream antiviral genes, whereas its knockdown had opposite effects and attenuated viral replication. in addition, gpatch3-deficient cells had higher ifnb1 mrna level compared with control cells after rna virus infection. mechanistically, gpatch3 was recruited to visa in a viral infection dependent manner and the assembly of visa/traf6/tbk1 signalosome was impaired in gpatch3-overexpressing cells. in contrast, upon viral infection, the recruitment of traf6 and tbk1 to visa was enhanced in gpatch3 deficient cells. taking together, our findings demonstrate that gpatch3 interacts with visa and disrupts the assembly of virus-induced visa signalosome therefore acts as a negative regulator of rlr-mediated innate antiviral immune responses.
WOS关键词	NF-KAPPA-B ; IMMUNE-RESPONSE ; RIG-I ; ADAPTER PROTEIN ; G-PATCH ; MAVS ; INTERFERON ; ACTIVATION ; VIRUS ; IRF3
WOS研究方向	Microbiology ; Parasitology ; Virology
WOS类目	Microbiology ; Parasitology ; Virology
语种	英语
出版者	PUBLIC LIBRARY SCIENCE
WOS记录号	WOS:000402555700035
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373428
专题	武汉病毒研究所
通讯作者	Wang, Yan-Yi
作者单位	1.Chinese Acad Sci, Key Lab Special Pathogens & Biosafety, Wuhan Inst Virol, Wuhan, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Nie, Ying,Ran, Yong,Zhang, Hong-Yan,et al. Gpatch3 negatively regulates rlr-mediated innate antiviral responses by disrupting the assembly of visa signalosome[J]. Plos pathogens,2017,13(4):18.
APA	Nie, Ying.,Ran, Yong.,Zhang, Hong-Yan.,Huang, Zhe-Fu.,Pan, Zhao-Yi.,...&Wang, Yan-Yi.(2017).Gpatch3 negatively regulates rlr-mediated innate antiviral responses by disrupting the assembly of visa signalosome.Plos pathogens,13(4),18.
MLA	Nie, Ying,et al."Gpatch3 negatively regulates rlr-mediated innate antiviral responses by disrupting the assembly of visa signalosome".Plos pathogens 13.4(2017):18.

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