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	Chevrier's field mouse (apodemus chevrieri) and psre david's vole (eothenomys melanogaster) in china carry orthohepeviruses that form two putative novel genotypes within the species orthohepevirus c
	Wang, Bo1,4; Li, Wen1; Zhou, Ji-Hua2; Li, Bei1; Zhang, Wei1; Yang, Wei-Hong2; Pan, Hong2; Wang, Li-Xia3; Bock, C. Thomas4,5; Shi, Zheng-Li1
刊名	Virologica sinica
	2018-02-01
卷号	33期号:1页码:44-58
关键词	Hepatitis e virus (hev) Orthohepevirus Genetic diversity Complete genome Chevrier's field mouse Pere david's vole
ISSN号	1674-0769
DOI	10.1007/s12250-018-0011-8
通讯作者	Zhang, yun-zhi(zhangyunzhi1818@163.com) ; Yang, xing-lou(yangxl@wh.iov.cn)
英文摘要	Hepatitis e virus (hev) is the prototype of the family hepeviridae and the causative agent of common acute viral hepatitis. genetically diverse hev-related viruses have been detected in a variety of mammals and some of them may have zoonotic potential. in this study, we tested 278 specimens collected from seven wild small mammal species in yunnan province, china, for the presence and prevalence of orthohepevirus by broad-spectrum reverse transcription (rt)-pcr. hev-related sequences were detected in two rodent species, including chevrier's field mouse (apodemus chevrieri, family muridae) and psre david's vole (eothenomys melanogaster, family cricetidae), with the infection rates of 29.20% (59/202) and 7.27% (4/55), respectively. further four representative full-length genomes were generated: two each from chevrier's field mouse (named rdhevac14 and rdhevac86) and psre david's vole (rdhevem40 and rdhevem67). phylogenetic analyses and pairwise distance comparisons of whole genome sequences and amino acid sequences of the gene coding regions showed that orthohepeviruses identified in chinese chevrier's field mouse and psre david's vole belonged to the species orthohepevirus c but were highly divergent from the two assigned genotypes: hev-c1 derived from rat and shrew, and hev-c2 derived from ferret and possibly mink. quantitative real-time rt-pcr demonstrated that these newly discovered orthohepeviruses had hepatic tropism. in summary, our work discovered two putative novel genotypes orthohepeviruses preliminarily named hev-c3 and hev-c4 within the species orthohepevirus c, which expands our understanding of orthohepevirus infection in the order rodentia and gives new insights into the origin, evolution, and host range of orthohepevirus.
WOS关键词	HEPATITIS-E VIRUS ; RATS RATTUS-NORVEGICUS ; UNITED-STATES ; WILD RATS ; FAMILY HEPEVIRIDAE ; CLASSIFICATION ; INFECTION ; CAMELS ; BATS
WOS研究方向	Virology
WOS类目	Virology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000428287700004
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373322
专题	武汉病毒研究所
通讯作者	Zhang, Yun-Zhi; Yang, Xing-Lou
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, Key Lab Special Pathogens & Biosafety, Wuhan 430070, Hubei, Peoples R China 2.Yunnan Inst Endem Dis Control & Prevent, Yunnan Prov Key Lab Zoonosis Control & Prevent, Dali 671000, Peoples R China 3.Dali Univ, Sch Publ Hlth, Dali 671000, Peoples R China 4.Robert Koch Inst, Dept Infect Dis, D-13353 Berlin, Germany 5.Univ Tubingen, Inst Trop Med, D-72076 Tubingen, Germany
推荐引用方式 GB/T 7714	Wang, Bo,Li, Wen,Zhou, Ji-Hua,et al. Chevrier's field mouse (apodemus chevrieri) and psre david's vole (eothenomys melanogaster) in china carry orthohepeviruses that form two putative novel genotypes within the species orthohepevirus c[J]. Virologica sinica,2018,33(1):44-58.
APA	Wang, Bo.,Li, Wen.,Zhou, Ji-Hua.,Li, Bei.,Zhang, Wei.,...&Yang, Xing-Lou.(2018).Chevrier's field mouse (apodemus chevrieri) and psre david's vole (eothenomys melanogaster) in china carry orthohepeviruses that form two putative novel genotypes within the species orthohepevirus c.Virologica sinica,33(1),44-58.
MLA	Wang, Bo,et al."Chevrier's field mouse (apodemus chevrieri) and psre david's vole (eothenomys melanogaster) in china carry orthohepeviruses that form two putative novel genotypes within the species orthohepevirus c".Virologica sinica 33.1(2018):44-58.

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