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	Intrahippocampal infusion of interleukin-6 impairs avoidance learning in rats
	Ma, TC; Zhu, XZ
刊名	Acta pharmacologica sinica
	1997-03-01
卷号	18期号:2页码:121-123
关键词	Interleukin-6 Nitric oxide Avoidance learning Hippocampus Nitroprusside
ISSN号	0253-9756
通讯作者	Ma, tc()
英文摘要	Aim: to study the effect of intrahippocampal infusion of interleukin-6 (il-6) on active avoidance in rats and the possible involvement of nitric oxide (no). methods: using a shuttle-box model, the effects of bilaterally intrahippocampal infusion of il-6 3.2, 16, and 80 ng as well as sodium nitroprusside (snp) 400 ng on active avoidance were studied on d 8 after administration. the levels of nitrite as an index of no in the hippocampus were detected using a fluorometric assay 24 h after infusion of il-6 3.2 or 80 ng. results: il-6 16 and 80 ng impaired the acquisition performance of active avoidance by prolonging the latency of avoidance in training, but not the retention performance in testing. ig-6 80 ng and snp 400 ng also resulted in a marked impairment in acquisition performances by decreasing the rate bf avoidance, but not in retention performances. il-6 80 ng markedly elevated the nitrite levels from 10.6 +/- 0.7 in control rats to 13,6 +/- 2.0 (nmol/g wet wt) (p < 0.01). il-6 3.2 ng had no effect on active avoidance nor on nitrite levels. conclusion: intrahippocampal infusion of il-6 impaired learning acquisition of active avoidance in rats.
WOS关键词	HIPPOCAMPAL NITRIC-OXIDE ; MEMORY ; INHIBITION ; NO
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
WOS类目	Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
语种	英语
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:A1997WM32200007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373298
专题	武汉病毒研究所
通讯作者	Ma, TC
作者单位	CHINESE ACAD SCI,SHANGHAI INST MAT MED,DEPT PHARMACOL,SHANGHAI 200031,PEOPLES R CHINA
推荐引用方式 GB/T 7714	Ma, TC,Zhu, XZ. Intrahippocampal infusion of interleukin-6 impairs avoidance learning in rats[J]. Acta pharmacologica sinica,1997,18(2):121-123.
APA	Ma, TC,&Zhu, XZ.(1997).Intrahippocampal infusion of interleukin-6 impairs avoidance learning in rats.Acta pharmacologica sinica,18(2),121-123.
MLA	Ma, TC,et al."Intrahippocampal infusion of interleukin-6 impairs avoidance learning in rats".Acta pharmacologica sinica 18.2(1997):121-123.

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