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	The regulation of cgas
	Xiong, Meiguang; Wang, Suyun; Wang, Yan-Yi; Ran, Yong
刊名	Virologica sinica
	2018-04-01
卷号	33期号:2页码:117-124
关键词	Cgas Dna sensing Regulation Autoimmune
ISSN号	1674-0769
DOI	10.1007/s12250-018-0005-6
通讯作者	Ran, yong(ranyong@wh.iov.cn)
英文摘要	The cgas-mita pathway of cytosolic dna sensing plays essential roles in immune response against pathogens that contain dna or with dna production in their life cycles. the cgas-mita pathway also detects leaked or aberrant accumulated self dna in the cytoplasm under certain pathological conditions, such as virus induced cell death, dna damage, mitochondria damage, gene mutations, which results in autoimmune diseases. therefore, the cgas-mita pathway must be tightly controlled to ensure proper immune response against pathogens and to avoid autoimmune diseases. the regulation of cgas-mita pathway at mita-level have been extensively explored and reviewed elsewhere, here we provide a summary and perspective on recent advances in understanding of the cgas regulation.
WOS关键词	CYCLIC GMP-AMP ; DNA SENSOR CGAS ; INNATE IMMUNE-RESPONSE ; CYTOSOLIC DNA ; SENSING PATHWAY ; STING PATHWAY ; ACTIVATION ; PROTEIN ; SYNTHASE ; VIRUS
WOS研究方向	Virology
WOS类目	Virology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000431413000001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373270
专题	武汉病毒研究所
通讯作者	Ran, Yong
作者单位	Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Xiong, Meiguang,Wang, Suyun,Wang, Yan-Yi,et al. The regulation of cgas[J]. Virologica sinica,2018,33(2):117-124.
APA	Xiong, Meiguang,Wang, Suyun,Wang, Yan-Yi,&Ran, Yong.(2018).The regulation of cgas.Virologica sinica,33(2),117-124.
MLA	Xiong, Meiguang,et al."The regulation of cgas".Virologica sinica 33.2(2018):117-124.

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