| The nicotinamide nucleotide transhydrogenase gene could impair blood glucose level stability and increase basal metabolism | |
| Soudy, Fathia1,2; Asif, Akhtar Rasool1,4; Miao, Yuanxin1; Jing, Lu1; Luan, Yu1; Saleem, Ali Haider4; Zohaib, Ali3; Muhammad, Sayyed Aun4; Ahmad, Zulfiqar5; Zhao, Shuhong1 | |
| 刊名 | Pakistan journal of agricultural sciences
 |
| 2018-06-01 | |
| 卷号 | 55期号:3页码:603-609 |
| 关键词 | Nnt Blood glucose Familial glucocorticoid deficiency Glucose metabolism Autosomal recessive disorder Feed conversion ratio Mice |
| ISSN号 | 0552-9034 |
| DOI | 10.21162/pakjas/18.6449 |
| 通讯作者 | Li, xinyun(xyli@mail.hzau.edu.cn) |
| 英文摘要 | C57bl/6j (b6j) is the most widely used mouse strain for metabolic research. it carries a spontaneous mutation in the nicotinamide nucleotide transhydrogenase (nnt) gene. this study compared blood glucose levels in b6j and kunming (km) mice as control. it was observed that blood glucose levels in b6j and km mice at 4 weeks of age decreased post feeding and reached the lowest level at 24 hr of fasting. blood glucose was significantly higher in b6j mice than that in km mice at 0 hr, 2 hr and 10 hr of fasting. in addition, the correlation between the nnt gene, growth traits and the feed conversion efficiency ratio (fcr) in (b6j x km) f2 generation (n = 342) was also analyzed. we found that nnt was significantly associated with body weight at 3 weeks (ibw) (p<0.01) and 5 weeks (fbw) (p<0.05) and average metabolic body weight (ambw) (p<0.01) but was not associated with average daily feed intake (afi), average daily gain (adg) and fcr. furthermore, qrt-pcr revealed that the expression levels of glut-1, glut-2, akt-1, irs-1 and ucp-2 genes were significantly different in high and low-fcr mice. our study offers novel evidence of the roles of nnt gene in metabolism and growth. |
| WOS研究方向 | Agriculture |
| WOS类目 | Agriculture, Multidisciplinary |
| 语种 | 英语 |
| 出版者 | UNIV AGRICULTURE, FAC VETERINARY SCIENCE |
| WOS记录号 | WOS:000435467700017 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2373258 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Li, Xinyun |
| 作者单位 | 1.Huazhong Agr Univ, Key Lab Agr Anim Genet Breeding & Reprod, Coll Anim Sci & Vet Med, Minist Educ, Wuhan 430070, Hubei, Peoples R China 2.Benha Univ, Dept Genet & Genet Engn, Toukh 13736, Kalyobiya, Egypt 3.Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Hubei, Peoples R China 4.Subcampus Univ Vet & Anim Sci, Coll Vet & Anim Sci, Lahore 54000, Pakistan 5.Islamia Univ Bahawalpur, Univ Coll Agr & Environm Sci, Dept Food Sci & Technol, Bahawalpur, Pakistan |
| 推荐引用方式 GB/T 7714 | Soudy, Fathia,Asif, Akhtar Rasool,Miao, Yuanxin,et al. The nicotinamide nucleotide transhydrogenase gene could impair blood glucose level stability and increase basal metabolism[J]. Pakistan journal of agricultural sciences,2018,55(3):603-609. |
| APA | Soudy, Fathia.,Asif, Akhtar Rasool.,Miao, Yuanxin.,Jing, Lu.,Luan, Yu.,...&Li, Xinyun.(2018).The nicotinamide nucleotide transhydrogenase gene could impair blood glucose level stability and increase basal metabolism.Pakistan journal of agricultural sciences,55(3),603-609. |
| MLA | Soudy, Fathia,et al."The nicotinamide nucleotide transhydrogenase gene could impair blood glucose level stability and increase basal metabolism".Pakistan journal of agricultural sciences 55.3(2018):603-609. |
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