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	Herpes simplex virus type 2 immediate early protein icp27 inhibits ifn-beta production in mucosal epithelial cells by antagonizing irf3 activation
	Guan, Xinmeng1,2; Zhang, Mudan3; Fu, Ming1,2; Luo, Sukun4; Hu, Qinxue1,5
刊名	Frontiers in immunology
	2019-02-26
卷号	10页码:14
关键词	Hsv-2 Icp27 Epithelial cells Ifn-beta Irf3
ISSN号	1664-3224
DOI	10.3389/fimmu.2019.00290
通讯作者	Zhang, mudan(mudan@wh.iov.cn) ; Hu, qinxue(qhu@wh.iov.cn)
英文摘要	Herpes simplex virus type 2 (hsv-2) is the main cause of genital herpes and infections are common in the lower genital tract. although neuronal and immune cells can be infected, epithelial cells, and keratinocytes are the primary hsv-2 target cells. hsv-2 establishes latency by evading the host immune system and its infection can also increase the risk of hiv-1 sexual transmission. our pervious study found that hsv-2 immediate early protein icp22, inhibited ifn-beta production by interfering with the irf3 pathway. however, icp22-null hsv-2 did not completely lose the capability of suppressing ifn-beta induction, suggesting the involvement of other viral components in the process. in this study, by using an ex vivo cervical explant model, we first demonstrated that hsv-2 can indeed inhibit ifn-beta induction in human mucosal tissues. we further identified hsv-2 immediate early protein icp27 as a potent ifn-beta antagonist. icp27 significantly suppresses the sendai virus or polyinosinic-polycytidylic acid-induced ifn-beta production in human mucosal epithelial cells, showing that icp27 inhibits the ifn-beta promoter activation, and ifn-beta production at both mrna and protein levels. additional studies revealed that icp27 directly associates with irf3 and inhibits its phosphorylation and nuclear translocation, resulting in the inhibition of ifn-beta induction. our findings provide insights into the molecular mechanism underlying hsv-2 mucosal immune evasion, and information for the design of hsv-2 mucosal vaccines.
WOS关键词	RIG-I ; CYTOSOLIC DNA ; INFECTION ; DOMAIN ; PATHOGENESIS ; RECOGNITION ; ASSOCIATION ; INTERFERONS ; EXPRESSION ; INDUCTION
WOS研究方向	Immunology
WOS类目	Immunology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000459675000001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373169
专题	武汉病毒研究所
通讯作者	Zhang, Mudan; Hu, Qinxue
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, Guangzhou Women & Childrens Med Ctr, Joint Ctr Translat Precis Med,Guangzhou Inst Pedi, Wuhan, Hubei, Peoples R China 4.Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan Childrens Hosp, Wuhan Maternal & Child Healthcare Hosp, Wuhan, Hubei, Peoples R China 5.St Georges Univ London, Inst Infect & Immun, London, England
推荐引用方式 GB/T 7714	Guan, Xinmeng,Zhang, Mudan,Fu, Ming,et al. Herpes simplex virus type 2 immediate early protein icp27 inhibits ifn-beta production in mucosal epithelial cells by antagonizing irf3 activation[J]. Frontiers in immunology,2019,10:14.
APA	Guan, Xinmeng,Zhang, Mudan,Fu, Ming,Luo, Sukun,&Hu, Qinxue.(2019).Herpes simplex virus type 2 immediate early protein icp27 inhibits ifn-beta production in mucosal epithelial cells by antagonizing irf3 activation.Frontiers in immunology,10,14.
MLA	Guan, Xinmeng,et al."Herpes simplex virus type 2 immediate early protein icp27 inhibits ifn-beta production in mucosal epithelial cells by antagonizing irf3 activation".Frontiers in immunology 10(2019):14.

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