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	Autophagy induced by low concentrations of crotonaldehyde promotes apoptosis and inhibits necrosis in human bronchial epithelial cells
	Wang, Limeng1,2,3; Li, Xiang1; Yang, Zhihua4; Zhu, Maoxiang4; Xie, Jianping1
刊名	Ecotoxicology and environmental safety
	2019-01-15
卷号	167页码:169-177
关键词	Crotonaldehyde Autophagy Apoptosis Necrosis Programmed cell deaths
ISSN号	0147-6513
DOI	10.1016/j.ecoenv.2018.10.008
通讯作者	Li, xiang(lixiang79ben@sina.com) ; Xie, jianping(ztridicp@126.com)
英文摘要	Crotonaldehyde is a common environmental contaminant. autophagy, apoptosis, and necrosis, were all respectively reported to be induced by crotonaldehyde. however, the relationships between programmed cell deaths, especially between autophagy and apoptosis, have not been elucidated. in the present study, alterations of autophagy, apoptosis and necrosis were investigated in human bronchial epithelial cells (beas-2b) exposed to crotonaldehyde, and effects of autophagy on apoptosis and necrosis were detected. we found that a high con- centration (160 mu mol/l mu m) of crotonaldehyde did not induce apoptosis, while a low concentration (80 mu m) of crotonaldehyde induced autophagy, apoptosis and necrosis. in 80 mu m crotonaldehyde-exposed beas-2b cells, autophagy and apoptosis exhibited a trend of increasing prior to decreasing with the increase of time, while the time point inducing the highest level of autophagy was 2 h, and that of apoptosis was 4 h. with the pretreatment of bafilomycin a(1), the apoptosis was inhibited and the necrosis was enhanced significantly in cells exposed to 80 mu m crotonaldehyde. autophagy mediated the induction of apoptosis via the intrinsic apoptotic pathway. the results indicate that autophagy mediates the initiation of apoptosis and plays a role in protecting from necrosis in low concentrations of crotonaldehyde-exposed beas-2b cells.
WOS关键词	ALPHA,BETA-UNSATURATED ALDEHYDES ; CHEMICAL CARCINOGENESIS ; DEPENDENT APOPTOSIS ; DNA-ADDUCTS ; DEOXYGUANOSINE ; IDENTIFICATION ; GENOTOXICITY ; INDUCTION ; RATS ; 1,3-BUTADIENE
WOS研究方向	Environmental Sciences & Ecology ; Toxicology
WOS类目	Environmental Sciences ; Toxicology
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000451360800020
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373029
专题	大连化学物理研究所
通讯作者	Li, Xiang; Xie, Jianping
作者单位	1.CNTC, Key Lab Tobacco Chem, Zhengzhou Tobacco Res Inst, 2 Fengyang St, Zhengzhou 450001, Henan, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China 3.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China 4.Beijing Inst Radiat Med, Dept Radiat Toxicol & Oncol, 27 Taiping Rd, Beijing 100850, Peoples R China
推荐引用方式 GB/T 7714	Wang, Limeng,Li, Xiang,Yang, Zhihua,et al. Autophagy induced by low concentrations of crotonaldehyde promotes apoptosis and inhibits necrosis in human bronchial epithelial cells[J]. Ecotoxicology and environmental safety,2019,167:169-177.
APA	Wang, Limeng,Li, Xiang,Yang, Zhihua,Zhu, Maoxiang,&Xie, Jianping.(2019).Autophagy induced by low concentrations of crotonaldehyde promotes apoptosis and inhibits necrosis in human bronchial epithelial cells.Ecotoxicology and environmental safety,167,169-177.
MLA	Wang, Limeng,et al."Autophagy induced by low concentrations of crotonaldehyde promotes apoptosis and inhibits necrosis in human bronchial epithelial cells".Ecotoxicology and environmental safety 167(2019):169-177.

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