In vivo growth-inhibition of S 180 tumor by mixture of 5-Fu and low molecular lambda-carrageenan from Chondrus ocellatus

doi:10.1016/j.phrs.2004.07.003

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	In vivo growth-inhibition of S 180 tumor by mixture of 5-Fu and low molecular lambda-carrageenan from Chondrus ocellatus
	Zhou, GF ; Xin, H ; Sheng, WX ; Sun, YP ; Li, Z ; Xu, ZH
刊名	PHARMACOLOGICAL RESEARCH
	2005-02-01
卷号	51 期号:2 页码:153-157
关键词	Low Molecular Lambda-carrageenan 5-fu Antitumor Immunocompetence
ISSN号	1043-6618
DOI	10.1016/j.phrs.2004.07.003
文献子类	Article
英文摘要	lambda-carrageenan is a sulfated galactan isolated from some red algae and have been reported to have many kinds of biological activities. Chondrus ocellatus is an important economic alga in China and many other parts of the world. The sample was obtained after lambda-carrageenan from the alga was degraded by microwave and its molecular weight is 9.3 kDa. In this study, tumor inhibiting activity of low molecular weight lambda-carrageenan and its mixture with 5-Fu on mice transplanted with S 180 tumor was investigated. Weight of immune organ, proliferation ratio of lymphocyte concentration of TNF-alpha and histopathology of spleen and tumor from the transplanted S 180 tumor mice were also deter-mined. Results indicated that the degraded lambda-carrageenan could enhance antitumor activity of 5-Fu and improve immunocompetence damaged by 5-Fu. (C) 2004 Published by Elsevier Ltd.; POLYSACCHARIDES; ANTICOAGULANT; SURVIVAL
学科主题	Pharmacology & Pharmacy
URL标识	查看原文
语种	英语
WOS记录号	WOS:000226559600009
公开日期	2010-12-22
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/3627]
专题	海洋研究所_其他
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Laiyang Agr Coll, Qingdao 266109, Peoples R China 4.Laiyang Hlth Sch, Dept Pathol, Laiyang 265200, Peoples R China
推荐引用方式 GB/T 7714	Zhou, GF,Xin, H,Sheng, WX,et al. In vivo growth-inhibition of S 180 tumor by mixture of 5-Fu and low molecular lambda-carrageenan from Chondrus ocellatus[J]. PHARMACOLOGICAL RESEARCH,2005,51(2):153-157.
APA	Zhou, GF,Xin, H,Sheng, WX,Sun, YP,Li, Z,&Xu, ZH.(2005).In vivo growth-inhibition of S 180 tumor by mixture of 5-Fu and low molecular lambda-carrageenan from Chondrus ocellatus.PHARMACOLOGICAL RESEARCH,51(2),153-157.
MLA	Zhou, GF,et al."In vivo growth-inhibition of S 180 tumor by mixture of 5-Fu and low molecular lambda-carrageenan from Chondrus ocellatus".PHARMACOLOGICAL RESEARCH 51.2(2005):153-157.