Bromophenol derivatives from the red alga Rhodomela confervoides

doi:10.1021/np030546+

	Bromophenol derivatives from the red alga Rhodomela confervoides
	Zhao, JL ; Fan, X ; Wang, SJ; Li, SA ; Shang, SQ ; Yang, YC ; Xu, NJ ; Lu, Y ; Shi, JG ; Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
刊名	JOURNAL OF NATURAL PRODUCTS
	2004-06-01
卷号	67 期号:6 页码:1032-1035
关键词	Odonthalia-corymbifera Polysiphonia-urceolata Methyltransferase Inhibitors Larix Acids
ISSN号	0163-3864
DOI	10.1021/np030546+
文献子类	Article
英文摘要	Eight new bromophenol derivatives, 2,3-dibromo-4,5-dihydroxybenzyl methyl sulfoxide (1), 4-(2,3-dibromo-4,5-dihydroxyphenyl)-3-butene-2-one (2), 2-(3-bromo-5-hydroxy-4-methoxyphenyl)-3-(2,3-dibromo-4,5-dihydroxyphenyl)propionic acid (3), 2-(3-bromo-5-hydroxy-4-methoxyphenyl)-3-(2,3-dibromo-4,5-dihydroxyphenyl)propionic acid methyl ester (4), 2-phenyl-3-(2,3-dibromo-4,5-dihydroxyphenyl)propionic acid (5), 4'-methoxy-2",3',3"-tribromo-4",5',5"-trihydroxydiphenylacetic acid (6), and 3-bromo-5-hydroxy-4-methoxyphenylacetic acid (7) and its methyl ester (8), together with a known bromophenol, 3-bromo-5-hydroxy4-methoxybenzoic acid (9), were isolated from the red alga Rhodomela confervoides. Their structures were elucidated by spectroscopic methods including IR, EIMS, FABMS, ESIMS, HRFABMS, HRESIMS, 1D and 2D NMR, and single-crystal X-ray structure analysis. Compounds 1-4, 8, and 9 were found inactive against several human cancer cell lines and microorganisms.; Eight new bromophenol derivatives, 2,3-dibromo-4,5-dihydroxybenzyl methyl sulfoxide (1), 4-(2,3-dibromo-4,5-dihydroxyphenyl)-3-butene-2-one (2), 2-(3-bromo-5-hydroxy-4-methoxyphenyl)-3-(2,3-dibromo-4,5-dihydroxyphenyl)propionic acid (3), 2-(3-bromo-5-hydroxy-4-methoxyphenyl)-3-(2,3-dibromo-4,5-dihydroxyphenyl)propionic acid methyl ester (4), 2-phenyl-3-(2,3-dibromo-4,5-dihydroxyphenyl)propionic acid (5), 4'-methoxy-2",3',3"-tribromo-4",5',5"-trihydroxydiphenylacetic acid (6), and 3-bromo-5-hydroxy-4-methoxyphenylacetic acid (7) and its methyl ester (8), together with a known bromophenol, 3-bromo-5-hydroxy4-methoxybenzoic acid (9), were isolated from the red alga Rhodomela confervoides. Their structures were elucidated by spectroscopic methods including IR, EIMS, FABMS, ESIMS, HRFABMS, HRESIMS, 1D and 2D NMR, and single-crystal X-ray structure analysis. Compounds 1-4, 8, and 9 were found inactive against several human cancer cell lines and microorganisms.
学科主题	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
URL标识	查看原文
语种	英语
WOS记录号	WOS:000222277100022
公开日期	2010-11-18
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/1889]
专题	海洋研究所_海洋生物技术研发中心
通讯作者	Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
作者单位	1.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 2.Peking Union Med Coll, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Zhao, JL,Fan, X,Wang, SJ,et al. Bromophenol derivatives from the red alga Rhodomela confervoides[J]. JOURNAL OF NATURAL PRODUCTS,2004,67(6):1032-1035.
APA	Zhao, JL.,Fan, X.,Wang, SJ.,Li, SA.,Shang, SQ.,...&Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China.(2004).Bromophenol derivatives from the red alga Rhodomela confervoides.JOURNAL OF NATURAL PRODUCTS,67(6),1032-1035.
MLA	Zhao, JL,et al."Bromophenol derivatives from the red alga Rhodomela confervoides".JOURNAL OF NATURAL PRODUCTS 67.6(2004):1032-1035.