Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis

doi:10.1080/07388551.2016.1272093

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	Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis
	Liu, Changshui 1,2; Ding, Yamei 2; Xian, Mo 1; Liu, Min 1; Liu, Huizhou 1; Ma, Qingjun 2; Zhao, Guang 1
刊名	CRITICAL REVIEWS IN BIOTECHNOLOGY
	2017
卷号	37 期号:7 页码:933-941
关键词	3-hydroxypropionate Malonyl-coa Pathway Metabolic Engineering Acetyl-coa Carboxylase Malonyl-coa Reductase Carbon Flux Enzyme Engineering Supply Of Energy And cOfactor 3hp Tolerance
DOI	10.1080/07388551.2016.1272093
文献子类	Review
英文摘要	3-Hydroxypropionate (3HP) is an attractive platform chemical, serving as a precursor to a variety of commodity chemicals like acrylate and acrylamide, as well as a monomer of a biodegradable plastic. To establish a sustainable way to produce these commercially important chemicals and materials, fermentative production of 3HP is widely investigated in recent years. It is reported that 3HP can be produced from several intermediates, such as glycerol, malonyl-CoA, and beta-alanine. Among all these biosynthetic routes, the malonyl-CoA pathway has some distinct advantages, including a broad feedstock spectrum, thermodynamic feasibility, and redox neutrality. To date, this pathway has been successfully constructed in various species including Escherichia coli, yeast and cyanobacteria, and optimized through carbon flux redirection, enzyme screening and engineering, and an increasing supply of energy and cofactors, resulting in significantly enhanced 3HP titer up to 40 g/L. These results show the feasibility of commercial manufacturing of 3HP and its derivatives in the future.
语种	英语
WOS记录号	WOS:000407365200009
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.qdio.ac.cn/handle/337002/143082]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Liu, Changshui,Ding, Yamei,Xian, Mo,et al. Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis[J]. CRITICAL REVIEWS IN BIOTECHNOLOGY,2017,37(7):933-941.
APA	Liu, Changshui.,Ding, Yamei.,Xian, Mo.,Liu, Min.,Liu, Huizhou.,...&Zhao, Guang.(2017).Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis.CRITICAL REVIEWS IN BIOTECHNOLOGY,37(7),933-941.
MLA	Liu, Changshui,et al."Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis".CRITICAL REVIEWS IN BIOTECHNOLOGY 37.7(2017):933-941.