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	Conidiogenones H and I, Two New Diterpenes of Cyclopiane Class from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S
	Gao, Shu-Shan1,2; Li, Xiao-Ming1; Zhang, Yi3; Li, Chun-Shun1; Wang, Bin-Gui1
刊名	CHEMISTRY & BIODIVERSITY
	2011-09-01
卷号	8期号:9页码:1748-1753
ISSN号	1612-1872
文献子类	Article
英文摘要	Two new tetracyclic diterpenes of the rarely reported cyclopiane class, conidiogenones H and I (1 and 2, resp.), along with five related congeners, conidiogenones B - D and F (3-5 and 6, resp.) and conidiogenol (7), were characterized from the culture extracts of Penicillium chrysogenum QEN-24S, an endophytic fungus derived from an unidentified marine red algal species of the genus Laurencia. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The inhibitory activity of theses diterpenes against four bacteria and one pathogen fungus was evaluated. Conidiogenone B (3) showed potent activity against Methicillin resistant Staphylococcus aureus (MRSA), Pseudomonas fluorescens, P. aeruginosa, and Staphylococcus epidermidis (each with a MIC value of 8 mu g/ml), while conidiogenol (7) showed obvious activity against P. fluorescens and S. epidermidis (each with a MIC value of 16 mu g/ml). This is the first report on antimicrobial activity of cyclopiane diterpenes.; Two new tetracyclic diterpenes of the rarely reported cyclopiane class, conidiogenones H and I (1 and 2, resp.), along with five related congeners, conidiogenones B - D and F (3-5 and 6, resp.) and conidiogenol (7), were characterized from the culture extracts of Penicillium chrysogenum QEN-24S, an endophytic fungus derived from an unidentified marine red algal species of the genus Laurencia. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The inhibitory activity of theses diterpenes against four bacteria and one pathogen fungus was evaluated. Conidiogenone B (3) showed potent activity against Methicillin resistant Staphylococcus aureus (MRSA), Pseudomonas fluorescens, P. aeruginosa, and Staphylococcus epidermidis (each with a MIC value of 8 mu g/ml), while conidiogenol (7) showed obvious activity against P. fluorescens and S. epidermidis (each with a MIC value of 16 mu g/ml). This is the first report on antimicrobial activity of cyclopiane diterpenes.
学科主题	Biochemistry & Molecular Biology ; Chemistry
语种	英语
WOS记录号	WOS:000295257200011
公开日期	2012-07-03
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/11818]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Dalian Jiaotong Univ, Sch Environm & Chem Engn, Dalian 116028, Peoples R China
推荐引用方式 GB/T 7714	Gao, Shu-Shan,Li, Xiao-Ming,Zhang, Yi,et al. Conidiogenones H and I, Two New Diterpenes of Cyclopiane Class from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S[J]. CHEMISTRY & BIODIVERSITY,2011,8(9):1748-1753.
APA	Gao, Shu-Shan,Li, Xiao-Ming,Zhang, Yi,Li, Chun-Shun,&Wang, Bin-Gui.(2011).Conidiogenones H and I, Two New Diterpenes of Cyclopiane Class from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S.CHEMISTRY & BIODIVERSITY,8(9),1748-1753.
MLA	Gao, Shu-Shan,et al."Conidiogenones H and I, Two New Diterpenes of Cyclopiane Class from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S".CHEMISTRY & BIODIVERSITY 8.9(2011):1748-1753.

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