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	Benzodiazepine Alkaloids from Marine-Derived Endophytic Fungus Aspergillus ochraceus
	Cui, Chuan-Ming1,2; Li, Xiao-Ming1; Li, Chun-Shun1; Sun, Hao-Fen1; Gan, Shu-Shan1,2; Wang, Bin-Gui1
刊名	HELVETICA CHIMICA ACTA
	2009
卷号	92期号:7页码:1366-1370
关键词	Niger En-13 Polysiphonia-urceolata Red Alga Circumdatin
ISSN号	0018-019X
文献子类	Article
英文摘要	A new fungus-derived benzodiazepine analogue, 2-hydroxycircumdatin C (1), and a compound which has been isolated from a natural resource for the first time, but has been previously synthesized, namely (11aS)-2,3-dihydro-7-methoxy-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione (2), along with five structurally related known alkaloids (3-7), were isolated from Aspergillus ochraceus, an endophytic fungus derived from the marine brown alga Sargassum kjellmanianum. Their structures were established on the basis of spectroscopic methods. The absolute configuration of I was determined through CD evidence. Compound 1 displayed significant DPPH radical-scavenging activity with an IC(50) value of 9.9 mu M, which is 8.9-fold more potent than that of butylated hydroxytoluene (BHT), a well-known synthetic positive control.; A new fungus-derived benzodiazepine analogue, 2-hydroxycircumdatin C (1), and a compound which has been isolated from a natural resource for the first time, but has been previously synthesized, namely (11aS)-2,3-dihydro-7-methoxy-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione (2), along with five structurally related known alkaloids (3-7), were isolated from Aspergillus ochraceus, an endophytic fungus derived from the marine brown alga Sargassum kjellmanianum. Their structures were established on the basis of spectroscopic methods. The absolute configuration of I was determined through CD evidence. Compound 1 displayed significant DPPH radical-scavenging activity with an IC50 value of 9.9 mu M, which is 8.9-fold more potent than that of butylated hydroxytoluene (BHT), a well-known synthetic positive control.
学科主题	Chemistry, Multidisciplinary
语种	英语
WOS记录号	WOS:000268622500016
公开日期	2010-12-22
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/2891]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Cui, Chuan-Ming,Li, Xiao-Ming,Li, Chun-Shun,et al. Benzodiazepine Alkaloids from Marine-Derived Endophytic Fungus Aspergillus ochraceus[J]. HELVETICA CHIMICA ACTA,2009,92(7):1366-1370.
APA	Cui, Chuan-Ming,Li, Xiao-Ming,Li, Chun-Shun,Sun, Hao-Fen,Gan, Shu-Shan,&Wang, Bin-Gui.(2009).Benzodiazepine Alkaloids from Marine-Derived Endophytic Fungus Aspergillus ochraceus.HELVETICA CHIMICA ACTA,92(7),1366-1370.
MLA	Cui, Chuan-Ming,et al."Benzodiazepine Alkaloids from Marine-Derived Endophytic Fungus Aspergillus ochraceus".HELVETICA CHIMICA ACTA 92.7(2009):1366-1370.

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