An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years
	Li, Chun-Huan 1; Zhang, Jia-Yao 1; Zhang, Xiu-Yun 1; Li, Sheng-Hong2 ; Gao, Jin-Ming 1
刊名	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
	2019-03-15
卷号	166 页码:400-416
关键词	Grayanane diterpenoids Ericaceae Bioactivities Analgesic activity Anti-inflammatory activity PTP1B inhibitory activity Structure-activity relationship
ISSN号	0223-5234
英文摘要	Grayanane diterpenoids, possessing a unique 5/7/6/5 tetracyclic system, exist exclusively in plants of the Ericaceae family. Owing to their various skeletons, complex structures, and diverse bioactivities, grayanoids have been the topic of research in many phytochemical and pharmacological laboratories, offering opportunities for the development of new drugs with analgesic, anti-inflammatory, and protein tyrosine phosphatase 1B (PTP1B) properties. Recently, a number of new grayanane diterpenoids with unprecedented carbon skeletons have been obtained from plants of the Ericaceae family, and they exhibit diverse biological properties, such as agalgesic, antinociceptive, anticancer, antiviral, antifeedant, insecticidal, toxicity, and PTP1B. In this review, 162 new grayanoids with 14 carbon skeletons from the Ericaceae family over the past seven years (2012 October 2018) are discussed, including their occurrence and distribution, skeleton types, structural features, biological activities, and structure-activity relationships (SARs). Also, strategies for the structural elucidation are summarized to provide useful information for medicinal chemists in developing potent anticancer, antiviral, analgesic, anti-inflammatory, and novel PTP1B agents. (C) 2019 Elsevier Masson SAS. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/65189]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Li, Sheng-Hong; Gao, Jin-Ming
作者单位	1.Northwest A&F Univ, Shaanxi Key Lab Nat Prod & Chem Biol, Coll Chem & Pharm, Yangling 712100, Shaanxi, Peoples R China 2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Li, Chun-Huan,Zhang, Jia-Yao,Zhang, Xiu-Yun,et al. An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2019,166:400-416.
APA	Li, Chun-Huan,Zhang, Jia-Yao,Zhang, Xiu-Yun,Li, Sheng-Hong,&Gao, Jin-Ming.(2019).An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,166,400-416.
MLA	Li, Chun-Huan,et al."An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 166(2019):400-416.