The Biogenesis, Functions, and Challenges of Circular RNAs | |
Li, Xiang1; Chen, Ling-Ling1,2; Yang, Li2,3 | |
刊名 | MOLECULAR CELL |
2018 | |
卷号 | 71期号:3页码:428-442 |
关键词 | Long Noncoding Rnas Exon Circularization Processed Pseudogenes Xenopus-tropicalis Messenger-rnas Human Genome Reveals Identification Transcription Expression |
ISSN号 | 1097-2765 |
DOI | 10.1016/j.molcel.2018.06.034 |
文献子类 | Review |
英文摘要 | Covalently closed circular RNAs (circRNAs) are produced by precursor mRNA back-splicing of exons of thousands of genes in eukaryotes. circRNAs are generally expressed at low levels and often exhibit cell-type-specific and tissue-specific patterns. Recent studies have shown that their biogenesis requires spliceosomal machinery and can be modulated by both cis complementary sequences and protein factors. The functions of most circRNAs remain largely unexplored, but known functions include sequestration of microRNAs or proteins, modulation of transcription and interference with splicing, and even translation to produce polypeptides. However, challenges exist at multiple levels to understanding of the regulation of circRNAs because of their circular conformation and sequence overlap with linear mRNA counterparts. In this review, we survey the recent progress on circRNA biogenesis and function and discuss technical obstacles in circRNA studies. |
电子版国际标准刊号 | 1097-4164 |
WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
语种 | 英语 |
WOS记录号 | WOS:000440569500008 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3491] |
专题 | 生化所2018年发文 上海生化细胞研究所_上海生科院生化细胞研究所 |
通讯作者 | Chen, Ling-Ling; Yang, Li |
作者单位 | 1.Univ Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol,Chinese Acad Sc, Shanghai Key Lab Mol Androl,State Key Lab Mol Bio, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 2.Univ Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, Shanghai Inst Biol Sci,Chinese Acad Sci, Shanghai Inst Nutr & Hlth,Key Lab Computat Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 3.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Xiang,Chen, Ling-Ling,Yang, Li. The Biogenesis, Functions, and Challenges of Circular RNAs[J]. MOLECULAR CELL,2018,71(3):428-442. |
APA | Li, Xiang,Chen, Ling-Ling,&Yang, Li.(2018).The Biogenesis, Functions, and Challenges of Circular RNAs.MOLECULAR CELL,71(3),428-442. |
MLA | Li, Xiang,et al."The Biogenesis, Functions, and Challenges of Circular RNAs".MOLECULAR CELL 71.3(2018):428-442. |
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