PD-1 Controls Follicular T Helper Cell Positioning and Function | |
Shi, Jingwen1,2,3,4,5; Hou, Shiyue1,2,3,5; Fang, Qian1,2,3,4,5; Liu, Xin1,2,3,5; Qi, Hai1,2,3,4,5; Liu, Xiaolong6 | |
刊名 | IMMUNITY |
2018 | |
卷号 | 49期号:2页码:264-+ |
关键词 | Germinal Center Formation Chronic Viral-infection B-cells Death 1 Differentiation Activation Generation Expression Induction Responses |
ISSN号 | 1074-7613 |
DOI | 10.1016/j.immuni.2018.06.012 |
文献子类 | Article |
英文摘要 | Follicular T helper (Tfh) cells highly express the programmed cell death-1 (PD-1) molecule. Whereas inhibition of T cell receptor (TCR) signaling and CD28 co-stimulation is thought to be the primary mode of PD-1 functions, whether and how PD-1 regulates Tfh cell development and function is unclear. Here we showed that, when engaged by the ensemble of bystander B cells constitutively expressing PD-1 ligand 1 (PD-L1), PD-1 inhibited T cell recruitment into the follicle. This inhibition involved suppression of PI3K activities downstream of the follicle-guidance receptor CXCR5, was independent of co-signaling with the TCR, and necessitated ICOS signaling to overcome. PD-1 further restricted CXCR3 upregulation on Tfh cells, serving to concentrate these cells toward the germinal center territory, where PD-L1-PD-1 interactions between individual Tfh and B cells optimized B cell competition and affinity maturation. Therefore, operating in both costimulation- independent and -dependent manners, PD-1 controls tissue positioning and function of Tfh cells. |
电子版国际标准刊号 | 1097-4180 |
WOS研究方向 | Immunology |
语种 | 英语 |
WOS记录号 | WOS:000442354500012 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3449] |
专题 | 生化所2018年发文 上海生化细胞研究所_上海生科院生化细胞研究所 |
通讯作者 | Qi, Hai |
作者单位 | 1.Tsinghua Univ, Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China; 2.Tsinghua Univ, Inst Immunol, Lab Dynam Immunobiol, Beijing 100084, Peoples R China; 3.Tsinghua Univ, Sch Med, Dept Basic Med Sci, Beijing 100084, Peoples R China; 4.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China; 5.Tsinghua Univ, Beijing Key Lab Immunol Res Chron Dis, Beijing 100084, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol,Ctr Excellence Mol Cell S, Shanghai 200031, Peoples R China |
推荐引用方式 GB/T 7714 | Shi, Jingwen,Hou, Shiyue,Fang, Qian,et al. PD-1 Controls Follicular T Helper Cell Positioning and Function[J]. IMMUNITY,2018,49(2):264-+. |
APA | Shi, Jingwen,Hou, Shiyue,Fang, Qian,Liu, Xin,Qi, Hai,&Liu, Xiaolong.(2018).PD-1 Controls Follicular T Helper Cell Positioning and Function.IMMUNITY,49(2),264-+. |
MLA | Shi, Jingwen,et al."PD-1 Controls Follicular T Helper Cell Positioning and Function".IMMUNITY 49.2(2018):264-+. |
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